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Organoid Technology: Current Standing and Future Perspectives Publisher Pubmed



Shariati L1, 2 ; Esmaeili Y3 ; Haghjooy Javanmard S1 ; Bidram E1, 3 ; Amini A4, 5
Authors
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Authors Affiliations
  1. 1. Department of Biomaterials, Nanotechnology and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Applied Physiology Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Biosensor Research Center, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Mechanical Engineering, Australian College of Kuwait, Mishref, Safat, Kuwait
  5. 5. Centre for Infrastructure Engineering, Western Sydney University, Penrith, NSW, Australia

Source: Stem Cells Published:2021


Abstract

Organoids are powerful systems to facilitate the study of individuals' disorders and personalized treatments. This emerging technology has improved the chance of translatability of drugs for preclinical therapies and mimicking of the complexity of organs, proposing numerous approaches for human disease modeling, tissue engineering, drug development, diagnosis, and regenerative medicine. In this review, we outline the history of organoid technology and summarize its faithful applications, and then we discuss the challenges and limitations encountered by three-dimensional organoids. Finally, we propose that human organoids offer a basic mechanistic infrastructure for “human modeling” systems to prescribe personalized medicines. © 2021 AlphaMed Press.
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