Estimation of Oxidative Stress and Serum Mineral (Ca, Mg, P) Status in Hashimoto’S Thyroiditis Patients



Rad NR¹ ; Kalirad A² ; Zavarreza J³ ; Vakili M⁴ Show Affiliations
Source: International Journal of Pharmaceutical and Clinical Research Published:2016

Abstract

Background: Thyroid hormones have a crucial physiological role in maintaining the balance of the body’s metabolism. These hormones also play an important role in the metabolism of the bone system. On the other hand, oxidative stress has been implicated in the pathogenesis of several inflammatory and immune-mediated disorders including Hashimoto’s thyroiditis. Therefore, the present study has aimed to find the changes in the serum calcium, phosphorous, and magnesium levels, and to evaluate the effect of HT on the body’s antioxidant status. Methods: The studied people consisted of 86 subjects, who were divided into two groups: 43 individuals with Hashimoto’s thyroiditis (HT) and 43 age-matched healthy individuals. This research checked the amounts of total triiodothyronine (T3), total thyroxine (T4), thyroid stimulating hormone (TSH), and also the mineral status and some other antioxidant status parameters. Results: It was observed that the mean TSH and SOD levels were increased significantly in HT patients (1.56 ± 0.73), compared to the control group (1.09 ± 0.62). On the other hand, the levels of T4, Ca, and Mg were meaningfully lower in HT patients, compared to the control group (P < 0.05). However, there was no significant difference in the mean of T3, P, and PON-1, between the hypothyroidism and control groups (P < 0.05). Conclusion: The obtained outcomes established this hypothesis that people with HT have an elevated oxidative stress and a decreased mineral level. Therefore, the importance of monitoring the levels of those antioxidant capabilities and the mineral status in HT patients before treatment became more evident. © 2016, International Journal of Pharmaceutical and Clinical Research. All rights reserved.