Assessment of Response Rate in Patients With Gestational Trophoblastic Neoplasia: A Case Study of Healthcare Centers in Isfahan From 2011 to 2016 Publisher



Far FB¹ ; Eghbali K² ; Seresht LM¹ Show Affiliations
Source: Journal of Obstetrics, Gynecology and Cancer Research Published:2019

Abstract

Background & Objective: Gestational trophoblastic neoplastia (GTN), as one of the curable malignancies all around the world, has a higher incidence rate in developing countries. Accordingly, investigating its behavior, risk factors, and reasons of treatment failure is of prime importance in such countries. Materials & Methods: This descriptive cross-sectional study examined the medical records of GTN cases in referral university hospitals in Isfahan from 2011 to 2016 to evaluate the risk factors affecting treatment response rate. The patients were divided into two groups of low-risk and high-risk and studied based on the International Federation of Gynecology and Obstetrics (FIGO) scoring system. Results: Out of a total of 70 GTN patients, 59 were classified into the low-risk group and 11 into the high-risk group. 100% of the patients in the low-risk group and 90.1% of the patients in the high-risk group responded to the first and second line treatments. In the follow-up, one case of recurrence in low-risk patients and one case of mortality in high-risk patients were reported. In the high-risk metastatic group, there was one case of unusual metastasis site at the kidney and the most common site of distant metastasis was lung. Conclusion: Response rate in the low-risk GTN patients was excellent (100%) and it was more than 90% in the high-risk GTN patients. Therefore, if GTN patients are treated in referral centers, the response rate will be favorable. Patients with brain metastases have good chances of recovery if treated timely. © 2019, Farname Inc. All rights reserved.