In Vivo Synaptic Potency, Short-Term and Long-Term Plasticity at the Hippocampal Schaffer Collateral-Ca1 Synapses: Role of Different Light

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In Vivo Synaptic Potency, Short-Term and Long-Term Plasticity at the Hippocampal Schaffer Collateral-Ca1 Synapses: Role of Different Light–Dark Cycles in Male Rats Publisher Pubmed

Radahmadi M¹ ; Salehifard K¹ ; Reisi P¹

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1. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Brain Research Published:2023

Abstract

The changes in the light–dark (L/D) cycle could modify cellular mechanisms in some brain regions. The present study compared the effects of various L/D cycles on in vivo synaptic potency, short-term and long-term plasticity in the hippocampal CA1 area, adrenal glands weight (AGWs), corticosterone (CORT) levels, and body weight differences (BWD) in male rats. Male rats were assigned into different L/D cycle groups: L4/D20, L8/D16, L12/D12 (control), L16/D8, and L20/D4. The slope, amplitude, and the area under curve (AUC) related to the field excitatory postsynaptic potentials (fEPSPs) were assessed, using the input–output (I/O) functions, paired-pulse (PP) responses at different interpulse intervals, and after the induction of long-term potentiation (LTP) in the hippocampal CA1 area. Also, the CORT levels, AGWs, and BWDs were measured in all groups. The slope, amplitude, and AUC of fEPSP in the I/O functions, all three phases of PP, before and after the LTP induction, were significantly decreased in all experimental groups, especially in the L20/D4 and L4/D20 groups. As such, the CORT levels and AGWs were significantly increased in all experimental groups, especially in the L20/D4 group. Overall, the uncommon L/D cycles (minimum and particularly maximum durations of light) significantly reduced the cellular mechanism of learning and memory. Also, downtrends were observed in synaptic potency, as well as short-term and long-term plasticity. The changes in PP with high interpulse intervals, or activity of GABAB receptors, were more significant than the changes in other PP phases with different L/D durations. Additionally, the CORT levels, adrenal glands, and body weight gain occurred time-independently concerning different L/D lengths. © 2023

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Style	Citing Format
MLA	Radahmadi M, Salehifard K, Reisi P. "In Vivo Synaptic Potency, Short-Term and Long-Term Plasticity at the Hippocampal Schaffer Collateral-Ca1 Synapses: Role of Different Light–Dark Cycles in Male Rats." Brain Research, vol. 1817, no. , 2023, pp. -.
APA	Radahmadi M, Salehifard K, Reisi P (2023). In Vivo Synaptic Potency, Short-Term and Long-Term Plasticity at the Hippocampal Schaffer Collateral-Ca1 Synapses: Role of Different Light–Dark Cycles in Male Rats. Brain Research, 1817(), -.
Chicago	Radahmadi M, Salehifard K, Reisi P. "In Vivo Synaptic Potency, Short-Term and Long-Term Plasticity at the Hippocampal Schaffer Collateral-Ca1 Synapses: Role of Different Light–Dark Cycles in Male Rats." Brain Research 1817, no. (2023): -.
Harvard	Radahmadi M, Salehifard K, Reisi P (2023) 'In Vivo Synaptic Potency, Short-Term and Long-Term Plasticity at the Hippocampal Schaffer Collateral-Ca1 Synapses: Role of Different Light–Dark Cycles in Male Rats', Brain Research, 1817(), pp. -.
Vancouver	Radahmadi M, Salehifard K, Reisi P. In Vivo Synaptic Potency, Short-Term and Long-Term Plasticity at the Hippocampal Schaffer Collateral-Ca1 Synapses: Role of Different Light–Dark Cycles in Male Rats. Brain Research. 2023;1817():-.
BibTex	@article{ author = {Radahmadi M and Salehifard K and Reisi P}, title = {In Vivo Synaptic Potency, Short-Term and Long-Term Plasticity at the Hippocampal Schaffer Collateral-Ca1 Synapses: Role of Different Light–Dark Cycles in Male Rats}, journal = {Brain Research}, volume = {1817}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Radahmadi M AU - Salehifard K AU - Reisi P TI - In Vivo Synaptic Potency, Short-Term and Long-Term Plasticity at the Hippocampal Schaffer Collateral-Ca1 Synapses: Role of Different Light–Dark Cycles in Male Rats JO - Brain Research VL - 1817 IS - SP - EP - PY - 2023 ER -

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