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A Case of Ochronosis With Gout and Monckeberg Arteries Publisher Pubmed



Karimzadeh H1 ; Mohtasham N1 ; Karimifar M1 ; Salesi M1 ; Bonakdar ZS1
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Authors Affiliations
  1. 1. Rheumatology Department, Isfahan University for Medical Sciences, Alzahra Hospital, Isfahan, Soffe Avenue, Iran

Source: Rheumatology International Published:2009


Abstract

Alkaptonuria is an inborn error of amino acid metabolism. A defect in tyrosine metabolism that results in accumulation of homogentisic acid in connective tissue, especially cartilage, has long been known. Degenerative arthropathy, especially of the knee and spine, develops at a relatively early age in adults. Accumulation also occurs in heart valves, and there may be a predisposition to atherosclerosis. We describe a 72-year-old man with ochronosis, gouty arthritis of both hands, and monckeberg arteries. © 2009 Springer-Verlag.
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