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The Association of High Risk Human Papillomaviruses in Patients With Cervical Cancer: An Evidence Based Study on Patients With Squamous Cell Dysplasia or Carcinoma for Evaluation of 23 Human Papilloma Virus Genotypes Publisher



Piroozmand A1, 2 ; Zadeh SMM3 ; Madani A4 ; Soleimani R5 ; Nedaeinia R6, 7 ; Niakan M8 ; Avan A9 ; Manian M10 ; Moradi M11 ; Eftekhar Z12
Authors
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Authors Affiliations
  1. 1. Microbiology Department, Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Autoimmune Diseases Research Center, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Central Lab, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
  5. 5. Department of Biology, Payame Noor University of Isfahan, Isfahan, Iran
  6. 6. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Microbiology Department, Deputy of Food and Drug, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Microbiology Department, Faculty of Medicine, Shahed University of Medical Sciences, Tehran, Iran
  9. 9. Molecular Medicine Group, Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  10. 10. Neurosciences Research Center, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  11. 11. Shahed University of Medical Sciences, Tehran, Iran
  12. 12. Department of Gynecology and Obstetrics, Mirza Khoochak Khan Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Jundishapur Journal of Microbiology Published:2016


Abstract

Background: Cervical cancer is one of the leading causes of cancer-related death in females. Human papilloma virus (HPV) is the major risk factor of cervical cancer. Objectives: The aim of the current study was to explore the frequency and role of 23 different HPVs in patients with cervical cancer. Materials and Methods: Overall, 117 formalin-fix and paraffin-embedded (FFPE) tissues from cervical cancer patients with squamous cell carcinoma (SCC) or dysplasia were collected from Mirza-Kochakkhan-Jangali hospital, Tehran, Iran during year 2013, to investigate the presence of HPV- HPV- 67, 68, 6, 11, 13, 16, 17, 30, 69, 39, 40, 42, 64, 66 and 51 to 59 genotypes. Results: The Pap smear report illustrated the presence of malignancy in 71 cases, while 11 cases had no evidence of malignancy. Among the patients, 26 cases had sexually transmitted disease with relative frequency of 0.58. Infection with papilloma virus was observed in 83.6% of SCC patients and 45% of the dysplasia group. The most prevalent HPV genotypes were 18 with 31.62% and 16 with 27.35% of cases. Moreover the relative frequencies of HPV-33, -6, -58, -52, -35 and -51, genotypes were 15.38, 7.69, 5.98, 5.12 and 3.41%, respectively. Among the different genotypes of HPV, 31 had the lowest and 16 had the highest relative frequency. Conclusions: Our findings demonstrate that HPV-16 and -18 have a higher prevalence in our population than 31 and 51. Further investigations are required to evaluate the role of these genotypes in a larger multicenter setting for establishing their values for early detection of patients, which is useful for screening and vaccination programs of cancerous and precancerous lesions of cervical cancer. © 2016, Ahvaz Jundishapur University of Medical Sciences.
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