Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Evaluation of Cholesterol Synthesis and Absorption Pathways in Patients With Cardiovascular Diseases Publisher

Summary: Study in Iran shows slightly higher cholestanol levels in patients with coronary artery disease, hinting at cholesterol absorption's role. Could guide better heart disease management. #HeartHealth #Cholesterol

Amirkhani F1 ; Namazi G2 ; Hayatmoghadam B1 ; Pourfarzam M3
Authors

Source: Journal of Isfahan Medical School Published:2019


Abstract

Background: Nowadays, coronary artery diseases (CADs) are among the most common diseases in societies. The aim of this study was to study the interplay between cholesterol absorption and synthesis in two groups of Iranian patients with CAD by measuring the markers of cholesterol synthesis and absorption pathways in plasma. Methods: The study population included 128 patients undergoing clinically indicated coronary angiography. Patients were divided into two groups after scoring the severity of their coronary stenosis; the S-stenosis group (patients with CAD, n = 75) had a significant stenosis indicated by coronary angiography, and the second group, N-stenosis (n = 55), had no significant coronary stenosis. Fasting plasma samples were used to measure cholesterol absorption and synthesis markers by gas chromatography-mass spectrometry (GC-MS). Findings: The level of cholesterol absorption markers in patients with coronary artery stenosis was slightly increased compared to patients without coronary artery stenosis, but this change was statistically significant only for cholestanol (P < 0.050). In terms of cholesterol synthesis markers, the results did not show any significant differences between the two groups (P > 0.050 for all). Conclusion: Study of cholesterol synthesis and absorption markers has not been reported in Iranian patients before. This article reports the results of such study for the first time. Considering the high prevalence of CADs and the importance of cholesterol metabolism in pathology of these diseases, the results may be used to understand some underlying mechanisms of development and progression of these diseases, and to manage the patient better. © 2019, Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. Cholesterol Synthesis and Absorption Markers in Type 2 Diabetes Mellitus, Journal of Isfahan Medical School (2019)
2. Is Friedewald Formula a Good Estimation for Low Density Lipoprotein Level in Iranian Population?, Journal of Research in Medical Sciences (2012)
3. Fatty Acid Composition of Hdl Phospholipids and Coronary Artery Disease, Journal of Clinical Lipidology (2009)
Experts (# of related papers)
View all Related Experts
Nizal Sarrafzadegan (6)
Morteza Pourfarzam (3)
Evaluation of Cholesterol Synthesis and Absorption Pathways in Patients With Cardiovascular Diseases
Other Related Docs
4. Investigation of Membrane Fatty Acid Profiles in Erythrocytes of Patients With Stable Coronary Artery Disease, Journal of Clinical Lipidology (2016)
5. Effects of Dietary Supplementation With Ghee, Hydrogenated Oil, or Olive Oil on Lipid Profile and Fatty Streak Formation in Rabbits, ARYA Atherosclerosis (2012)
6. Risk Factors for Coronary Artery Disease in Isfahan, Iran, European Journal of Public Health (1999)
7. Comparison of Equations for the Calculation of Ldl-Cholesterol in Familial Hypercholesterolemia: Data From Iranian Registry, Turk Kardiyoloji Dernegi Arsivi (2022)
8. Association Between Severity of Coronary Disease and Apolipoproteins a and B, Iranian Journal of Endocrinology and Metabolism (2011)
9. Association of High Level of Hs-Crp With In-Stent Restenosis: A Case-Control Study, Cardiovascular Revascularization Medicine (2019)
10. Lipid and Glucose Serum Levels in Children With Congenital Heart Disease, Journal of Tehran University Heart Center (2014)
11. Serum Paraoxonase 1 Activity Is Associated With Fatty Acid Composition of High Density Lipoprotein, Disease Markers (2013)
12. Low-Density Lipoprotein Cholesterol and Risk of Type 2 Diabetes: The Isfahan Diabetes Prevention Study, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2018)
13. Apo B Versus Cholesterol in Estimating Cardiovascular Risk and in Guiding Therapy: Report of the Thirty-Person/Ten-Country Panel, Journal of Internal Medicine (2006)
14. Investigating the Inflammatory Status in the Patients Candidate for Second Angiography After Coronary Stent Implantation, Acta Cardiologica (2023)
15. Suppressive Impact of Anethum Graveolens Consumption on Biochemical Risk Factors of Atherosclerosis in Hypercholesterolemic Rabbits, International Journal of Preventive Medicine (2013)
16. First Iranian Guidelines for the Diagnosis, Management, and Treatment of Hyperlipidemia in Adults, Journal of Research in Medical Sciences (2024)
17. L-Arginine Supplementation Influenced Nitrite But Not Nitrate and Total Nitrite in Rabbit Model of Hypercholesterolemia, Iranian Biomedical Journal (2008)
18. Dietary Inflammatory Index in Relation to Severe Coronary Artery Disease in Iranian Adults, Frontiers in Nutrition (2023)
19. Hypolipidemic Activity of Allium Porrum L. in Cholesterol-Fed Rabbits, Journal of Medicinal Food (2006)
20. The Effects of Phytochemicals on Serum Triglycerides in Subjects With Hypertriglyceridemia: A Systematic Review of Randomized Controlled Trials, Phytotherapy Research (2023)