Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
A Femoral Shape Porous Scaffold Bio-Nanocomposite Fabricated Using 3D Printing and Freeze-Drying Technique for Orthopedic Application Publisher



Du X1 ; Dehghani M2 ; Alsaadi N3 ; Nejad MG4 ; Sabersamandari S5 ; Toghraie D6 ; Su CH7 ; Nguyen HC8
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Orthopaedics, The First Hospital of Lanzhou University, Lanzhou, 730000, Gansu, China
  2. 2. Department of Orthopedic Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Industrial Engineering, Faculty of Engineering Rabigh Branch, King Abdulaziz University, Jeddah, 21589, Saudi Arabia
  4. 4. Industrial Engineering Department, Girne American University, Kyrenia, 99428, TRNC, Turkey
  5. 5. New Technology Research Center, Amirkabir University of Technology, Tehran, Iran
  6. 6. Department of Mechanical Engineering, Khomeinishahr Branch, Islamic Azad University Khomeinishahr, Iran
  7. 7. Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City, 24301, Taiwan
  8. 8. Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, 700000, Viet Nam

Source: Materials Chemistry and Physics Published:2022


Abstract

The novel bio-nanocomposite scaffold provides a temporary environment for bone growth, and facilitates cell adhesion, growth, and differentiation. In the present study, a 3D printing method is used for fabricating bone scaffolds with wollastonite-hydroxyapatite (WS-HA) composed and chitosan polymer with the polycaprolactone (PCL). Wollastonite (WS) is used as a based ceramic material for chemical stabilizers, which accelerates the healing process, but this material's mechanical strength shows weak mechanical performance. After fabrication of the specimens using solid work and 3D machine, mechanical strength and biological behavior were investigated. Then, scanning electron microscopy (SEM) and X-ray diffraction (XRD) are used to analyze the morphology and phase structure of the architecture. After analyzing the SEM images, the porosity of the scaffolds using Images-J is measured, which indicates that it is similar within the normal bones. The simulated body fluid (SBF) is used for biological tests, and the swelling and absorption tests are performed on the scaffolds which show the hydrophilicity of the components due to their high adsorption power. The atomic structure of the three-component bio-nanocomposite WS-HA is simulated by ABAQUS software and their mechanical and physical properties are extracted. Then, a relationship was proposed to predict the mechanical properties of the WS-HA bio-nanocomposite. Also, a multi-objective problem, with no information related to the desirability of the objectives, is developed and optimized by the Global Criterion Method. Finally, it is concluded that the most suitable scaffold for orthopedic application is a sample with the highest amount of HA with 4.9 MPa compressive strength coated with chitosan. © 2021 Elsevier B.V.
Related Docs
View other Related Docs
1. Effect of Calcium Silicate Nanoparticle on Surface Feature of Calcium Phosphates Hybrid Bio-Nanocomposite Using for Bone Substitute Application, Powder Technology (2020)
2. Investigation of the Mechanical Properties of a Bony Scaffold for Comminuted Distal Radial Fractures: Addition of Akermanite Nanoparticles and Using a Freeze-Drying Technique, Journal of the Mechanical Behavior of Biomedical Materials (2021)
3. Application of 3D Bioprinters for Dental Pulp Regeneration and Tissue Engineering (Porous Architecture), Transport in Porous Media (2022)
4. Synthesize and Characterization of a Novel Cadmium Selenide Nanoparticle With Iron Precursor Applicable in Hyperthermia of Cancer Cells, International Journal of Nanoscience and Nanotechnology (2021)
5. Development and Investigation of Novel Alginate-Hyaluronic Acid Bone Fillers Using Freeze Drying Technique for Orthopedic Field, Nanomedicine Research Journal (2020)
6. Investigation the Mechanical Properties of a Novel Multicomponent Scaffold Coated With a New Bio-Nanocomposite for Bone Tissue Engineering: Fabrication, Simulation and Characterization, Journal of Materials Research and Technology (2021)
7. Fabrication of Elastin Additive on Polymethyl Methacrylate and Hydroxyapatite-Based Bioactive Bone Cement, Materials Chemistry and Physics (2022)
8. Improvement in Osseointegration of Tricalcium Phosphate-Zircon for Orthopedic Applications: An in Vitro and in Vivo Evaluation, Medical and Biological Engineering and Computing (2020)
Experts (# of related papers)
View all Related Experts
Saeed Karbasi (89)
Mohammad Rafienia (55)
Other Related Docs
9. A Porous Polymeric–Hydroxyapatite Scaffold Used for Femur Fractures Treatment: Fabrication, Analysis, and Simulation, European Journal of Orthopaedic Surgery and Traumatology (2020)
10. Fabrication and Finite Element Simulation of Antibacterial 3D Printed Poly L-Lactic Acid Scaffolds Coated With Alginate/Magnesium Oxide for Bone Tissue Regeneration, International Journal of Biological Macromolecules (2023)
11. Investigation of Addition of Calcium Phosphate Ceramic to Multilayer Scaffold for Bone Applications With Improved Mechanical Properties: Fuzzy Logic Analysis, Ceramics International (2023)
12. Nanostructure, Molecular Dynamics Simulation and Mechanical Performance of Pcl Membranes Reinforced With Antibacterial Nanoparticles, Journal of Applied and Computational Mechanics (2021)
13. Fabrication and Finite Element Simulation of 3D Printed Poly L-Lactic Acid Scaffolds Coated With Alginate/Carbon Nanotubes for Bone Engineering Applications, International Journal of Biological Macromolecules (2023)
14. Bioprinting of Three-Dimensional Scaffold Based on Alginate-Gelatin As Soft and Hard Tissue Regeneration, Journal of Materials Research and Technology (2021)
15. Synergetic Effect of Bioglass and Nano Montmorillonite on 3D Printed Nanocomposite of Polycaprolactone/Gelatin in the Fabrication of Bone Scaffolds, International Journal of Biological Macromolecules (2024)
16. Global Criterion Optimization Method for Improving the Porosity of Porous Scaffolds Containing Magnetic Nanoparticles: Fabrication and Finite Element Analysis, Materials Science and Engineering: B (2023)
17. Fabrication and Characterization of 3D Nanostructured Polycaprolactone-Gelatin/Nanohydroxyapatite-Nanoclay Scaffolds for Bone Tissue Regeneration, Journal of Polymers and the Environment (2024)
18. Analysis of Amorphous Structure With Polycaprolactone-Hydroxyapatite Nanoparticles Fabricated by 3D Bioprinter Technique for Bone Tissue Engineering, Ceramics International (2023)
19. Development of Porous Photopolymer Resin-Swcnt Produced by Digital Light Processing Technology Using for Bone Femur Application, Archives of Bone and Joint Surgery (2021)
20. Investigation of the Effect of Berkovich and Cube Corner Indentations on the Mechanical Behavior of Fused Silica Using Molecular Dynamics and Finite Element Simulation, Ceramics International (2022)
21. Therapy With New Generation of Biodegradable and Bioconjugate 3D Printed Artificial Gastrointestinal Lumen, Iranian Journal of Basic Medical Sciences (2021)
22. Fabrication and Characterization of 3D-Printed Composite Scaffolds of Coral-Derived Hydroxyapatite Nanoparticles/Polycaprolactone/Gelatin Carrying Doxorubicin for Bone Tissue Engineering, Journal of Materials Science: Materials in Medicine (2024)
23. Pcl/Agarose 3D-Printed Scaffold for Tissue Engineering Applications: Fabrication, Characterization, and Cellular Activities, Research in Pharmaceutical Sciences (2023)
24. 3D-Printed Bioactive Chitosan/Alginate /Hardystonite Scaffold for Bone Tissue Engineering: Synthesis and Characterization, Journal of Non-Crystalline Solids (2023)
25. Effects of Bioglass Nanoparticles on Bioactivity and Mechanical Property of Poly(3-Hydroxybutirate) Scaffolds, Scientia Iranica (2013)
26. The Influence of Bioglass Nanoparticles on the Biodegradation and Biocompatibility of Poly (3-Hydroxybutyrate) Scaffolds, International Journal of Artificial Organs (2012)
27. Electrospun Captopril-Loaded Pcl-Carbon Quantum Dots Nanocomposite Scaffold: Fabrication, Characterization, and in Vitro Studies, Polymers for Advanced Technologies (2020)
28. Mechanical Evaluation of Nhap Scaffold Coated With Poly-3-Hydroxybutyrate for Bone Tissue Engineering, Journal of Nanoscience and Nanotechnology (2013)
29. The Journey of Multifunctional Bone Scaffolds Fabricated From Traditional Toward Modern Techniques, Bio-Design and Manufacturing (2020)
30. Investigation of Physical, Mechanical and Biological Properties of Polyhydroxybutyrate-Chitosan/Graphene Oxide Nanocomposite Scaffolds for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2023)
31. Pepgen-P15 Delivery to Bone: A Novel 3D Printed Scaffold for Enhanced Bone Regeneration, Journal of Drug Delivery Science and Technology (2024)
32. Fabrication and Characterization of Hydroxyapatite-Coated Forsterite Scaffold for Tissue Regeneration Applications, Bulletin of Materials Science (2015)
33. Effects of Nano-Bioactive Glass on Structural, Mechanical and Bioactivity Properties of Poly (3-Hydroxybutyrate) Electrospun Scaffold for Bone Tissue Engineering Applications, Materials Technology (2019)
34. 3D Printed Polycaprolactone/Gelatin/Ordered Mesoporous Calcium Magnesium Silicate Nanocomposite Scaffold for Bone Tissue Regeneration, Journal of Materials Science: Materials in Medicine (2024)
35. Enhancing the Biological Characteristics of Aminolysis Surface-Modified 3D Printed Nanocomposite Polycaprolactone/Nanohydroxyapatite Scaffold Via Gelatin Biomacromolecule Immobilization: An in Vitro and in Vivo Study, Colloids and Surfaces B: Biointerfaces (2025)
36. In Vitro Studies of Polycaprolactone Nanofibrous Scaffolds Containing Novel Gehlenite Nanoparticles, Journal of Medical Signals and Sensors (2021)
37. Natural Hydroxyapatite/Diopside Nanocomposite Scaffold for Bone Tissue Engineering Applications: Physical, Mechanical, Bioactivity and Biodegradation Evaluation, Materials Technology (2022)
38. Calcitonin-Loaded Octamaleimic Acid–Silsesquioxane Nanoparticles in Hydrogel Scaffold Support Osteoinductivity in Bone Regeneration, Pharmaceutical Development and Technology (2021)
39. Physical and Mechanical Properties of a Poly-3-Hydroxybutyratecoated Nanocrystalline Hydroxyapatite Scaffold for Bone Tissue Engineering, Journal of Porous Materials (2012)
40. Preparation of a Novel Biodegradable Nanocomposite Scaffold Based on Poly (3-Hydroxybutyrate)/Bioglass Nanoparticles for Bone Tissue Engineering, Journal of Materials Science: Materials in Medicine (2010)
41. Polycaprolactone/Gelatin/Hydroxyapatite Nanocomposite Scaffold Seeded With Stem Cells From Human Exfoliated Deciduous Teeth to Enhance Bone Repair: In Vitro and in Vivo Studies, Materials Technology (2022)
42. Development of a 3D Bioprinted Alginate-Gelatin Hydrogel Scaffold Loaded With Calcium Phosphates for Dental Pulp Tissue Regeneration, Iranian Journal of Chemistry and Chemical Engineering (2025)
43. A Novel Flexible, Conductive, and Three-Dimensional Reduced Graphene Oxide/Polyurethane Scaffold for Cell Attachment and Bone Regeneration, Materials and Design (2022)
44. Incorporation of Nanohydroxyapatite and Vitamin D3 Into Electrospun Pcl/Gelatin Scaffolds: The Influence on the Physical and Chemical Properties and Cell Behavior for Bone Tissue Engineering, Polymers for Advanced Technologies (2018)
45. Highly Porous 3D Printed Scaffold Incorporated With Graphene Oxide-Merwinite and Coated With Igf1 Loaded Nanofibers for Calvarial Defect Repair, Journal of Polymers and the Environment (2024)
46. Preparation of Nanostructure Bioactive Diopside Scaffolds for Bone Tissue Engineering by Two Near Net Shape Manufacturing Techniques, Materials Letters (2016)
47. A Modular Approach to 3D-Printed Bilayer Composite Scaffolds for Osteochondral Tissue Engineering, Journal of Materials Science: Materials in Medicine (2024)
48. Poly (Glycerol Sebacate) and Polyhydroxybutyrate Electrospun Nanocomposite Facilitates Osteogenic Differentiation of Mesenchymal Stem Cells, Journal of Drug Delivery Science and Technology (2021)
49. A New Approach to Fabrication of Cs/Bg/Cnt Nanocomposite Scaffold Towards Bone Tissue Engineering and Evaluation of Its Properties, Applied Surface Science (2015)
50. Tunable Cellular Interactions and Physical Properties of Nanofibrous Pcl-Forsterite: Gelatin Scaffold Through Sequential Electrospinning, Composites Science and Technology (2013)