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Prevalence of Dyslipidemia in Iranian Children and Adolescents: A Systematic Review Publisher



Hovsepian S1 ; Kelishadi R1 ; Djalalinia S2, 3, 4 ; Farzadfar F2, 3 ; Naderimagham S3 ; Qorbani M2, 5
Authors
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Authors Affiliations
  1. 1. Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Non-communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Development of Research and Technology Center, Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran
  5. 5. Department of Community Medicine, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran

Source: Journal of Research in Medical Sciences Published:2015


Abstract

Background: Dyslipidemia is considered as an important modifi able risk factor for cardiovascular disease (CVD). Th e link between childhood dyslipidemia and occurrence of atherosclerosis and its sequels in adulthood are well-documented. Th is study aimed to systematically review the prevalence of dyslipidemia among Iranian children and adolescents. Materials and Methods: An electronic search was conducted on studies published from January 1990 to January 2014. Th e main international electronic data sources were PubMed and the NLM Gateway (for MEDLINE), Institute of Scientifi c Information (ISI), and SCOPUS. For Persian databases, we used domestic databases with systematic search capability including IranMedex, Irandoc, and Scientifi c Information Database (SID). We included all available population-based studies and national surveys conducted in the pediatric age group (aged <21 years). Results: In this review, 1772 articles were identifi ed (PubMed: 1464; Scopus: 11; ISI: 58; SID: 90; IranMedex: 149; Irandoc: 57). During three refi ne steps and after removing of duplicates, 182 articles related to the study domain were selected. After quality assessment, 46 studies were selected for text appraisal, of which 26 qualifi ed articles were evaluated at the fi nal step. Th e prevalence range of hypercholesterolemia, hypertriglyceridemia, elevated low-density lipoprotein cholesterol, and low high-density lipoprotein cholesterol (HDL-C) were 3-48%, 3-50%, 5-20% and 5-88%, respectively. Low HDL-C and hypertriglyceridemia were the most prevalent lipid disorders in this group of population. Conclusion: Dyslipidemia is a common health problem among Iranian children and adolescents. Few data were available in preschool children. Th is fi nding provides useful information for health policy makers to implement action-oriented interventions for prevention and early control of this important CVD risk factor. © 2015, Isfahan University of Medical Sciences(IUMS). All rights reserved.
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