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Angiosarcoma of the Temporal Bone: Case Report and Review of the Literature Publisher Pubmed



Bernstock JD1 ; Shafaat O2 ; Hardigan A3 ; Fox BM3 ; Moore LS4 ; Chagoya G3 ; Elsayed G3 ; Gessler F7 ; Ilyas A3 ; Yamashita D3 ; Mcgrew B4 ; Hackney J5 ; Sotoudeh H6
Authors
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Authors Affiliations
  1. 1. Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
  2. 2. Department of Radiology and Interventional Neuroradiology, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, United States
  4. 4. Department of Otolaryngology, University of Alabama at Birmingham, Birmingham, AL, United States
  5. 5. Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, United States
  6. 6. Department of Neuroradiology, University of Alabama at Birmingham, Birmingham, AL, United States
  7. 7. Department of Neurosurgery, Goethe University Hospital, Frankfurt, Germany

Source: World Neurosurgery Published:2019


Abstract

Background: Angiosarcomas are rare malignant tumors of endothelial origin. Nearly one half of all angiosarcomas occur in the head and neck. Temporal bone angiosarcomas are extremely uncommon. We present a case of temporal bone angiosarcoma and a review of the relevant data. Case Description: We present the case of a 20-year-old man with a painful right postauricular mass after a closed head injury. Radiologic studies demonstrated a large right osteolytic and heterogeneously enhancing mass. The patient underwent right transpetrosal craniectomy for resection. Histologic studies confirmed high-grade sarcoma. Immunohistochemical staining demonstrated a uniformly positive ERG endothelial marker, CD31 staining with cytoplasmic and membranous patterns of immunopositivity, positive nuclear staining for FLI-1, positive cytoplasmic and membranous staining for CD99 and STAT6, and negative smooth muscle actin stains in the neoplastic cells. Ki-67 staining showed ∼94% positivity in the neoplastic cell nuclei. Postoperative follow-up imaging studies demonstrated evidence of metastatic right cervical lymphadenopathy. Conclusions: Angiosarcoma of the temporal bone is extremely uncommon. In the present case report, we explored a relationship between trauma and angiosarcoma of the temporal bone. We reviewed the reported data regarding the pathogenesis, diagnosis, treatment, radiologic findings, and histologic characteristics of angiosarcoma of the temporal bone. © 2019 Elsevier Inc.
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