What Left for Us for Urinary Tract Infection Treatment? an Experience From the South of Iran Publisher

Summary: High resistance rates to common UTI antibiotics detected, especially in E. coli. Should clinicians reconsider empirical treatments? Nitrofurantoin remains effective. #Antibiotics #PublicHealth

Mahmoudi A ; Moghadami M ; Shirazi Yeganeh B ; Tabari P ; Moosavi M
Source: Advanced Biomedical Research Published:2021

Abstract

Background: The aim of the study is to define the prevalence and antimicrobial susceptibility pattern of bacteria from cases of urinary tract infections (UTIs). Materials and Methods: A retrospective analysis of urinary pathogens and their antimicrobial susceptibility was done on urine cultures at Shiraz University Laboratory from 2015 to 2017. Antimicrobial susceptibility tests have done using the disk-diffusion technique as per the standard of CSLI. Results: During 2 years of study, 3489 samples were culture positive. Escherichia coli was the dominant isolate (84%), followed by Klebsiella spp. (10.7%) and Enterococci spp. (2,2%). The overall resistance rates to trimethoprim-sulfamethoxazole, ceftriaxone, and ciprofloxacin were 56.1%, 47.2%, and 37% respectively. The most frequently isolated bacteria were E. coli, which had resistance rates of 58.6%, 49.1% to TMP-STX, and cefixime, also sensitivity rates of 95.1% to nitrofurantoin (FM). Conclusions: In the study area, resistance rates to fluoroquinolones and cephalosporins were high Because most isolates were sensitive to FM and aminoglycoside, they are suggested as appropriate antimicrobials for empirical treatment of UTIs before available urine culture results. © 2023 Elsevier B.V., All rights reserved.