Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
The Therapeutic Effects and Mechanisms of Action of Resveratrol on Polycystic Ovary Syndrome: A Comprehensive Systematic Review of Clinical, Animal and in Vitro Studies Publisher Pubmed

Summary: Review suggests resveratrol eases PCOS symptoms like insulin resistance. Could it be a therapy? #PCOS #NaturalRemedies

Karimi A1 ; Tutunchi H2 ; Naeini F3 ; Vajdi M4 ; Mobasseri M2 ; Najafipour F2
Authors

Source: Clinical and Experimental Pharmacology and Physiology Published:2022


Abstract

Polycystic ovary syndrome (PCOS) is one of the most important and common polygenic endocrine disorders among women of reproductive age. Resveratrol, a natural phenol, is involved in various biological activities, including antioxidant, antiseptic, anti-inflammatory, anti-ageing and anti-cancer effects. This systematic review aimed to investigate the therapeutic effects and mechanisms of actions of resveratrol in PCOS. The present study was conducted according to the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis statements. We searched PubMed, Science Direct, Google Scholar, Scopus, ISI Web of Science, ProQuest and Embase databases up to August 2021 by using the relative keywords. Original studies published in the English language that assessed the effects of resveratrol on PCOS and its associated complications were considered. Out of 417 records screened, only 24 articles met the inclusion criteria: 10 in vitro, 10 animal and 4 human studies. The results obtained in the present study showed that resveratrol supplementation might be effective in improving PCOS-related symptoms by reducing insulin resistance, alleviating dyslipidaemia, improving ovarian morphology and anthropometric indices, regulating the reproductive hormones and reducing inflammation and oxidative stress by affecting biological pathways. According to the available evidence, resveratrol may reduce the complications of PCOS. However, further studies are recommended for a comprehensive conclusion on the exact mechanism of resveratrol in PCOS patients. © 2022 John Wiley & Sons Australia, Ltd.
Related Docs
View other Related Docs
1. Therapeutic Effects of Organic Zinc on Reproductive Hormones, Insulin Resistance and Mtor Expression, As a Novel Component, in a Rat Model of Polycystic Ovary Syndrome, Iranian Journal of Basic Medical Sciences (2020)
2. Cardiometabolic Risk Factors in Polycystic Ovary Syndrome, Pakistan Journal of Medical Sciences (2012)
3. Effect of Resveratrol on Metabolic Syndrome Components: A Systematic Review and Meta-Analysis, Reviews in Endocrine and Metabolic Disorders (2019)
Experts (# of related papers)
View all Related Experts
Hatav GhasemiTehrani (5)
Ferdous Mehrabian (4)
The Therapeutic Effects and Mechanisms of Action of Resveratrol on Polycystic Ovary Syndrome: A Comprehensive Systematic Review of Clinical, Animal and in Vitro Studies
Other Related Docs
4. Effect of Metformin on Serum Ferritin Level in Women With Polycystic Ovary Syndrome, Iranian Red Crescent Medical Journal (2011)
5. Resveratrol May Mildly Improve Renal Function in the General Adult Population: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials, Nutrition Research (2023)
6. The Effect of N-3 Polyunsaturated Fatty Acid Supplementation on Androgen Status in Patients With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Clinical Trials, Hormone and Metabolic Research (2016)
7. Therapeutic Potential of Resveratrol in Diabetic Nephropathy According to Molecular Signaling, Current Molecular Pharmacology (2022)
8. The Effects of Curcumin Supplementation on Glycemic Status, Lipid Profile and Hs-Crp Levels in Overweight/Obese Women With Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Complementary Therapies in Medicine (2019)
9. Association Between Major Dietary Patterns and Polycystic Ovary Syndrome: Evidence From a Case-Control Study, Applied Physiology, Nutrition and Metabolism (2019)
10. Global Prevalence of Polycystic Ovary Syndrome in Women Worldwide: A Comprehensive Systematic Review and Meta-Analysis, Archives of Gynecology and Obstetrics (2024)
11. Comparison of the Effect of Auriculotherapy, a Herbal Compound (Aslagh Capsule), and Metformin on the Clinical Symptoms of Polycystic Ovary Syndrome: Randomized Clinical Trial, Advanced Biomedical Research (2024)
12. The Effect of Concentrated Pomegranate Juice Consumption on Risk Factors of Cardiovascular Diseases in Women With Polycystic Ovary Syndrome: A Randomized Controlled Trial, Phytotherapy Research (2021)
13. The Effect of Concentrated Pomegranate Juice on Biomarkers of Inflammation, Oxidative Stress, and Sex Hormones in Overweight and Obese Women With Polycystic Ovary Syndrome: A Randomized Controlled Trial, Phytotherapy Research (2023)
14. Omega-3 Supplementation Effects on Polycystic Ovary Syndrome Symptoms and Metabolic Syndrome, Journal of Research in Medical Sciences (2017)
15. Comparison of the Effects of Metformin, Flutamide Plus Oral Contraceptives, and Simvastatin on the Metabolic Consequences of Polycystic Ovary Syndrome, Journal of Research in Medical Sciences (2016)
16. Effect of Soy Phytoestrogen on Metabolic and Hormonal Disturbance of Women With Polycystic Ovary Syndrome, Journal of Research in Medical Sciences (2011)
17. The Prevalence of Metabolic Syndrome and Insulin Resistance According to the Phenotypic Subgroups of Polycystic Ovary Syndrome in a Representative Sample of Iranian Females, Journal of Research in Medical Sciences (2011)
18. Inulin-Type Fructans With Different Degrees of Polymerization Improve Insulin Resistance, Metabolic Parameters, and Hormonal Status in Overweight and Obese Women With Polycystic Ovary Syndrome: A Randomized Double-Blind, Placebo-Controlled Clinical Trial, Food Science and Nutrition (2024)
19. Relation Between Resveratrol and Diabetes, Journal of Isfahan Medical School (2014)
20. Effects of Probiotic Supplementation on Hormonal and Clinical Outcomes of Women Diagnosed With Polycystic Ovary Syndrome: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial, Journal of Functional Foods (2022)