Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Folic Acid and Coenzyme Q10 Ameliorate Cognitive Dysfunction in the Rats With Intracerebroventricular Injection of Streptozotocin



Dolatabadi HRD1 ; Reisi P2, 3 ; Alaei H2 ; Malekabadi HA4 ; Pilehvarian AA1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Basic Sciences, Isfahan Payame Noor University, Isfahan, Iran
  2. 2. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Biosensor Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Basic Sciences, Islamic Azad University Khorasgan Branch, Isfahan, Iran

Source: Iranian Journal of Basic Medical Sciences Published:2012

Abstract

Objective(s): The present study aimed to investigate the effects of a fat soluble antioxidant, coenzyme Q10 (CoQ10) and folic acid on learning and memory in the rats with intracerebroventricular injection of streptozotocin (ICVSTZ), an animal model of sporadic type of Alzheimer's disease. Materials and Methods: The lesion groups were injected bilaterally with ICV-STZ (1.5 mg/kg b.wt., in normal saline). In the treated groups, rats received folic acid (4 mg/kg; i.p.) or CoQ10 (10 mg/kg; i.p.), either alone or together, for 21 days. Passive avoidance learning test was used for evaluation of learning and memory. Results: The results showed that learning and memory performance was significantly impaired in the rats with ICVSTZ (P< 0.001), however CoQ10 and folic acid, either alone or together, prevented impairments significantly (P< 0.001), as there was not any significant difference between these treated lesion groups and control group. Conclusion: The present results suggest that CoQ10 and folic acid have therapeutic and preventive effects on cognitive impairments in Alzheimer's disease.
Related Docs
View other Related Docs
1. Effects of Folic Acid on Passive Avoidance Learning and Memory in Rat Alzheimer Model by Intracerebroventricular Injection of Streptozotocin, Journal of Isfahan Medical School (2010)
2. Erythropoietin Improves Spatial Learning and Memory in Streptozotocin Model of Dementia, Pathophysiology (2013)
3. The Effects of Erythropoietin on Learning and Memory in Rats With Alzheimer’S Disease, Journal of Isfahan Medical School (2011)
4. Evaluation of the Effects of Red Grape Juice on Alzheimer's Disease in Rats, Journal of Isfahan Medical School (2012)
5. Effect of Exercise on Learning and Memory in Rats After Intracerebroventricular Injection of Streptozotocin, Journal of Isfahan Medical School (2011)
6. Effect of Royal Jelly (Rj) on Learning and Memory in Rats After Intracerebroventricular Injection of Streptozotocin (Icv-Stz), Journal of Isfahan Medical School (2011)
7. Role of Anemia and Related Factors in Intentional Suicidal Attempts, Journal of Isfahan Medical School (2011)
8. Effect of Red Grape Juice on Learning and Passive Avoidance Memory in Rats, Journal of Isfahan Medical School (2010)
Experts (# of related papers)
View all Related Experts
Hojatallah Alaei (20)
Parham Reisi (11)
Other Related Docs
9. Gallic Acid Ameliorates Lps-Induced Memory Decline by Modulating Nf-Κb, Tnf-Α, and Caspase 3 Gene Expression and Attenuating Oxidative Stress and Neuronal Loss in the Rat Hippocampus, Metabolic Brain Disease (2025)
10. Correlation Between Sperm Motility and Sperm Chromatin/Dna Damage Before and After Cryopreservation and the Effect of Folic Acid and Nicotinic Acid on Post-Thaw Sperm Quality in Normozoospermic Men, Cell and Tissue Banking (2019)
11. Effects of Ca1 Glutamatergic Systems Upon Memory Impairments in Cholestatic Rats, Behavioural Brain Research (2013)
12. Effects of Hydroalcoholic, Methanolic, and Hexane Extracts of Brown Algae Sargassum Angustifolium on Scopolamine-Induced Memory Impairment and Learning Deficit in Rodents, Research in Pharmaceutical Sciences (2023)
13. Protective Effects of Citicoline and Benfotiamine Each Alone and in Combination on Streptozotocin-Induced Memory Impairment in Mice, Clinical Psychopharmacology and Neuroscience (2020)
14. Crocin Improves Spatial Learning and Memory Deficits in the Morris Water Maze Via Attenuating Cortical Oxidative Damage in Diabetic Rats, Neuroscience Letters (2017)
15. The Role of Cyclooxygenase 2 in the Cognitive Impairment Induced by Alcohol or Stress in Rats, Advanced Biomedical Research (2021)
16. The Effect of Treadmill Running on Memory Before and After the Nbm-Lesion in Rats, Journal of Bodywork and Movement Therapies (2013)
17. Probiotics Treatment Improves Diabetes-Induced Impairment of Synaptic Activity and Cognitive Function: Behavioral and Electrophysiological Proofs for Microbiome-Gut-Brain Axis, Neuroscience (2013)
18. The Effect of Erythropoietin on Neuronal Apoptosis in Hippocampal Dentate Gyrus in Streptozotocin-Induced Alzheimer’S Disease in Rats, Journal of Isfahan Medical School (2018)
19. The Effect of Treadmill Running on Passive Avoidance Learning in Animal Model of Alzheimer Disease, International Journal of Preventive Medicine (2013)
20. Crocin Improves Cognitive Impairment in Lps-Treated Rats Through Anti-Apoptotic, Anti-Inflammatory, and Antioxidant Activities, Molecular Neurobiology (2024)
21. Coenzyme Q10 Supplementation and Oxidative Stress Parameters: A Systematic Review and Meta-Analysis of Clinical Trials, European Journal of Clinical Pharmacology (2020)
22. The Effect of Antioxidant Vitamins E and C on Cognitive Performance of the Elderly With Mild Cognitive Impairment in Isfahan, Iran: A Double-Blind, Randomized, Placebo-Controlled Trial, European Journal of Nutrition (2014)
23. Effects of Cyperus Rotundus Extract on Spatial Memory Impairment and Neuronal Differentiation in Rat Model of Alzheimer’S Disease, Advanced Biomedical Research (2020)
24. Effect of Hydro-Alcoholic Extract of Nigella Sativa on Cisplatin-Induced Memory Impairment and Brain Oxidative Stress Status in Male Rats, Avicenna Journal of Phytomedicine (2024)
25. The Effects of Acorus Calamus L. in Preventing Memory Loss, Anxiety, and Oxidative Stress on Lipopolysaccharide-Induced Neuroinflammation Rat Models, International Journal of Preventive Medicine (2018)
26. Quercetin Promotes Learning and Memory Performance Concomitantly With Neural Stem/Progenitor Cell Proliferation and Neurogenesis in the Adult Rat Dentate Gyrus, International Journal of Developmental Neuroscience (2019)
27. Saffron (Crocus Sativus L.) Extract Prevents and Improves D-Galactose and Nano 2 Induced Memory Impairment in Mice, EXCLI Journal (2012)
28. Effects of Crocin on Spatial or Aversive Learning and Memory Impairments Induced by Lipopolysaccharide in Rats, Avicenna Journal of Phytomedicine (2021)
29. Effects of Cholestasis on Learning and Locomotor Activity in Bile Duct Ligated Rats, Malaysian Journal of Medical Sciences (2014)
30. Comparative Effects of Chronic Administrations of Gabapentin, Pregabalin and Baclofen on Rat Memory Using Object Recognition Test, Research in Pharmaceutical Sciences (2017)
31. Effects of Carvacrol on Spatial Learning Performances, Hippocampal Interleukin-1ß Level and Oxidative Stress Markers in Lipopolysaccharide-Treated Rats, Physiology and Pharmacology (Iran) (2019)
32. The Dose-Dependent Neuroprotective Effect of Norepinephrine in Improving Memory Retrieval in an Experimental Model of Multiple Sclerosis, Experimental Autoimmune Encephalomyelitis, Brain Research Bulletin (2024)
33. Treadmill Running Improves Spatial Memory in an Animal Model of Alzheimer's Disease, Behavioural Brain Research (2011)
34. Effect of Acute and Chronic Hypertension on Short- and Long-Term Spatial and Avoidance Memory in Male Rats, Pathophysiology (2010)
35. Effects of Different Timing of Stress on Corticosterone, Bdnf and Memory in Male Rats, Physiology and Behavior (2015)
36. Role of Bdnf Signaling in the Neuroprotective and Memory-Enhancing Effects of Flavonoids in Alzheimer’S Disease, CNS and Neurological Disorders - Drug Targets (2024)
37. The Effect of Cinnamomum Zeylanicum Bark Water Extract on Memory Performance in Alloxan-Induced Diabetic Mice, Research in Pharmaceutical Sciences (2016)
38. Supplementation of Carvacrol Attenuates Hippocampal Tumor Necrosis Factor-Alpha Level, Oxidative Stress, and Learning and Memory Dysfunction in Lipopolysaccharide-Exposed Rats, Advanced Biomedical Research (2022)
39. Effects of Exercise on Spatial Memory Deficits Induced by Nucleus Basalis Magnocellularis Lesions, Physiology and Pharmacology (2009)
40. Protective Effect of Vitamin C, Vitamin B12 and Omega-3 on Leadinduced Memory Impairment in Rat, Research in Pharmaceutical Sciences (2016)
41. The Effect of Rosemary Extract on Spatial Memory, Learning and Antioxidant Enzymes Activities in the Hippocampus of Middle-Aged Rats, Medical Journal of the Islamic Republic of Iran (2015)
42. Neuroprotective Effects of Sesamol Against Lps-Induced Spatial Learning and Memory Deficits Are Mediated Via Anti-Inflammatory and Antioxidant Activities in the Rat Brain, Avicenna Journal of Phytomedicine (2023)
43. Effects of Piper Nigrum Fruit and Cinnamum Zeylanicum Bark Alcoholic Extracts, Alone and in Combination, on Scopolamine-Induced Memory Impairment in Mice, Research in Pharmaceutical Sciences (2021)
44. Therapeutic Effects of Cyperus Rotundus Rhizome Extract on Memory Impairment, Neurogenesis and Mitochondria in Beta-Amyloid Rat Model of Alzheimer’S Disease, Metabolic Brain Disease (2020)
45. The Effect of Co-Administration of Lactobacillus Probiotics and Bifidobacterium on Spatial Memory and Learning in Diabetic Rats, Tehran University Medical Journal (2012)
46. The Effect of Ghrelin on Antioxidant Status in the Rat's Model of Alzheimer's Disease Induced by Amyloid-Beta, BioMedicine (Taiwan) (2022)