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Successful Treatment of Lupoid Cutaneous Leishmaniasis With Glucantime and Topical Trichloroacetic Acid (A Case Report) Publisher Pubmed



Nilforoushzadeh MA1 ; Sadeghian G1 ; Jaffary F1, 2 ; Ziaei H3 ; Shiranibidabad L1 ; Mahzoni P4
Authors
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Authors Affiliations
  1. 1. Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Korean Journal of Parasitology Published:2008


Abstract

Lupoid leishmaniasis is a unique form of cutaneous leishmaniasis characterized by unusual clinical features and a chronic relapsing course, mostly caused by infection with Leishmania tropica. In this clinical form, 1-2 yr after healing of the acute lesion, new papules and nodules appear at the margin of the remaining scar. Herein, we describe a case of this clinical form that was resistant to 2 courses of treatments: systemic glucantime and then a combination therapy with allopurinol and systemic glucantime. However, marked improvement was seen after a combination therapy with topical trichloroacetic acid solution (50%) and systemic glucantime, and there were no signs of recurrence after 1 yr of follow-up.
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