Isfahan University of Medical Sciences

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Langerhans Cell Histiocytosis in a Child With Unifocal Mandibular Lesion and Diabetes Insipidus: A Case Report



Alian Z1 ; Hashemipour M1 ; Moaddab MH1
Authors
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Authors Affiliations
  1. 1. Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2010

Abstract

Background: Patients with Langerhans cell histiocytosis are at particularly high risk for central diabetes insipidus (CDI) due to hypothalamic-pituitary disease. Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the proliferation of specialized bone marrow-derived Langerhans cells and mature eosinophils. Three disease variants were included in this description, eosinophilic granuloma, Letterer - Siwe disease and Hand - Schuller - Christian syndrome. Case Reprort: We report a patient of Langerhans cell histiocytosis-solitary eosinophilic granuloma of the mandible that presented with diabetes insipitus after biopsy of mass.