Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Colon Specific Delivery of Budesonide Based on Triple Coated Pellets: In Vitro/In Vivo Evaluation Publisher Pubmed



Varshosaz J1 ; Emami J1 ; Tavakoli N1 ; Minaiyan M2 ; Rahmani N1 ; Dorkoosh F3 ; Mahzouni P4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmaceutics, Faculty of Pharmacy and Novel Drug Delivery, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pharmacology, Faculty of Pharmacy and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Clinical Pathology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Acta Pharmaceutica Published:2012


Abstract

Three layered pellets of budesonide were prepared for colon delivery by the extrusion-spheronization method. The coatings consisted of hydroxypropylmethyl cellulose (HPMC) (as barrier layer), Eudragit E (as rate controlling layer) and hydroxypropylmethyl cellulose acetate succinate (HPMC AS) (as enteric layer). The rate controlling layer was further modified using various pore formers. Dissolution studies were carried out at pH 1.2, 7.4 and 6.8. Pellet core composition and type and level of pore former affected the drug release from pellets. Pellets containing 20 % (m/m) citric acid in the cores coated with HPMC at a coating level of 6 % (m/m), Eudragit E containing Avicel RC 581 (30 %) as pore former at a coating level of 30 % (m/m) and HPMC AS at a coating level of 15 % (m/m) had the best release profiles. These pellets showed promising results in alleviating the conditions of an experimental model of colitis induced by trinitrobenzenesulfonic acid in rats.
Related Docs
View other Related Docs
1. Development of Novel Budesonide Pellets Based on Codes™ Technology: In Vitro/In Vivo Evaluation in Induced Colitis in Rats, DARU, Journal of Pharmaceutical Sciences (2011)
2. Pectin Film Coated Pellets for Colon-Targeted Delivery of Budesonide: In-Vitro/In-Vivo Evaluation in Induced Ulcerative Colitis in Rat, Iranian Journal of Pharmaceutical Research (2012)
3. Colon Delivery of Budesonide Using Solid Dispersion in Dextran for the Treatment and Secondary Prevention of Ulcerative Colitis in Rat, International Journal of Preventive Medicine (2010)
4. Preparation of Budesonide-Dextran Conjugates Using Glutarate Spacer As a Colon-Targeted Drug Delivery System: In Vitro/In Vivo Evaluation in Induced Ulcerative Colitis, Journal of Drug Targeting (2011)
5. Preparation and in Vitro/In Vivo Evaluation of Dextran Matrix Tablets of Budesonide in Experimental Ulcerative Colitis in Rats, Drug Delivery (2011)
6. Preparation and in Vitro Characterization of Piroxicam Enteric Coated Pellets Using Powder Layering Technique, Pharmaceutical Development and Technology (2009)
7. Preparation and Characterization of a Sustained Release Buccoadhesive System for Delivery of Terbutaline Sulfate, Research in Pharmaceutical Sciences (2013)
8. Formulation and in Vitro Characterization of Ciprofloxacin Floating and Bioadhesive Extended-Release Tablets, Drug Delivery (2006)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (24)
Jaber Emami Baferani (11)
Other Related Docs
9. Incorporation of Magnetic Nax Zeolite/Dox Into the Pla/Chitosan Nanofibers for Sustained Release of Doxorubicin Against Carcinoma Cells Death in Vitro, International Journal of Biological Macromolecules (2019)
10. Gold Nanoparticles Loaded Into Niosomes: A Novel Approach for Enhanced Antitumor Activity Against Human Ovarian Cancer, Advanced Powder Technology (2021)
11. Evaluation of Trigonella Foenum-Graecum Seeds Gum As a Novel Tablet Binder, International Journal of Pharmacy and Pharmaceutical Sciences (2012)
12. Formulation and Optimization of Solid Lipid Nanoparticle Formulation for Pulmonary Delivery of Budesonide Using Taguchi and Box-Behnken Design, Research in Pharmaceutical Sciences (2015)
13. Use of Enteric Polymers for Production of Microspheres by Extrusion-Spheronization, Pharmaceutica Acta Helvetiae (1997)
14. Evaluation of Release Kinetics and Mechanisms of Curcumin and Curcumin-Β-Cyclodextrin Inclusion Complex Incorporated in Electrospun Almond Gum/Pva Nanofibers in Simulated Saliva and Simulated Gastrointestinal Conditions, BioNanoScience (2019)
15. Preparation and Characterization of Solid Dispersions of Celecoxib Obtained by Spray-Drying Ethanolic Suspensions Containing Pvp-K30 or Isomalt, Journal of Drug Delivery Science and Technology (2018)
16. Development and Evaluation of Sustained-Release Propranolol Wax Microspheres, Journal of Microencapsulation (2001)
17. Development of a Prolonged-Release Gastroretentive Tablet Formulation of Ciprofloxacin Hydrochloride: Pharmacokinetic Characterization in Healthy Human Volunteers, International Journal of Pharmaceutics (2011)
18. Preparing Simvastatin Nanoparticles by a Combination of Ph-Sensitive and Timed-Release Approaches for the Potential Treatment of Ulcerative Colitis, Journal of Biomaterials Applications (2022)
19. Novel Caffeic Acid Nanocarrier: Production, Characterization, and Release Modeling, Journal of Nanomaterials (2013)
20. Microencapsulation of Matricine by a Dehydrating Liquid and Assessment of Its Retention, Daru (2002)
21. Use of Natural Gums and Cellulose Derivatives in Production of Sustained Release Metoprolol Tablets, Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents (2006)
22. Carboxymethyl Cellulose-Based Wafer Enriched With Resveratrol-Loaded Nanoparticles for Enhanced Wound Healing, Drug Delivery and Translational Research (2020)
23. Use of Hydrophilic Natural Gums in Formulation of Sustained-Release Matrix Tablets of Tramadol Hydrochloride, AAPS PharmSciTech (2006)
24. Three-Dimensional (3D) Printed Tablets Using Ethyl Cellulose and Hydroxypropyl Cellulose to Achieve Zero Order Sustained Release Profile, Cellulose (2020)
25. Development and Characterization of Buccoadhesive Nifedipine Tablets, European Journal of Pharmaceutics and Biopharmaceutics (2002)
26. Pulmonary Delivery of Docetaxel and Celecoxib by Plga Porous Microparticles for Their Synergistic Effects Against Lung Cancer, Anti-Cancer Agents in Medicinal Chemistry (2022)
27. Fabrication of Polymeric Nanoparticles of Poly(Ethylene-Co-Vinyl Acetate) Coated With Chitosan for Pulmonary Delivery of Carvedilol, Journal of Applied Polymer Science (2014)
28. Microencapsulation of Budesonide With Dextran by Spray Drying Technique for Colon-Targeted Delivery: An in Vitro/In Vivo Evaluation in Induced Colitis in Rat, Journal of Microencapsulation (2011)
29. Composite Hydrogel-Embedded Sucrose Stearate Niosomes: Unique Curcumin Delivery System, Food and Bioprocess Technology (2022)
30. Plant Pollen Grains: A Move Towards Green Drug and Vaccine Delivery Systems, Nano-Micro Letters (2021)
31. Solid Carriers for Improved Solubility of Glipizide in Osmotically Controlled Oral Drug Delivery System, Drug Development and Industrial Pharmacy (2007)
32. Preparation and Characterization of Metoprolol Controlled-Release Solid Dispersions, Drug Delivery (2006)
33. Effect of Tragacanth Gum–Chitin Nanofiber Film Containing Free or Nano-Encapsulated Cumin Essential Oil on the Quality of Chilled Turkey Burgers Packed With Oxygen Absorber, Food Science and Nutrition (2024)
34. Effectiveness of Budesonide-Succinate-Dextran Conjugate As a Novel Prodrug of Budesonide Against Acetic Acid-Induced Colitis in Rats, International Journal of Colorectal Disease (2010)
35. Simvastatin Nanosuspensions Prepared Using a Combination of Ph-Sensitive and Timed-Release Approaches for Potential Treatment of Colorectal Cancer, Pharmaceutical Development and Technology (2021)
36. Co-Encapsulation of Probiotics With Prebiotics and Their Application in Functional/Synbiotic Dairy Products, Critical Reviews in Food Science and Nutrition (2022)