Hydrochlorothiazide and Kidney Stone Recurrence; an In-Depth Analysis of the Nostone Trial Publisher



Ghazaani MZ¹ ; Rizi FSD¹ ; Malekpour E² ; Momeni E³ ; Abbasi F⁴ Show Affiliations
Source: Journal of Renal Injury Prevention Published:2024

Abstract

Kidney stones constitute a distressing and often recurring condition with increasing prevalence in the last decades. Despite successful outcomes following kidney stone treatment, the recurrence rate remains notably high. Thiazides have conventionally been the mainstay for preventing kidney stone recurrence, with studies exploring their efficacy at various doses. The NOSTONE study is an exceptional placebo-controlled randomized controlled trial on the effectiveness of different doses of hydrochlorothiazide in preventing kidney stones. Notably commendable for its methodological rigor and comprehensive approach, the study serves as a noteworthy contribution to advancing our understanding of kidney stone prevention strategies. Our study provides a critical evaluation of the NOSTONE study’s investigation into the effectiveness of hydrochlorothiazide in preventing the recurrence of kidney stones, with a primary emphasis on the statistical flaws identified within the NOSTONE study. © (2024), (Nickan Research Institute). All Rights Reserved.