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Cardiovascular Responses of the Anterior Claustrum; Its Mechanism; Contribution of Medial Prefrontal Cortex Publisher Pubmed



Hatam M1 ; Sheybanifar M2 ; Nasimi A3
Authors
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Authors Affiliations
  1. 1. Dept. of Physiology, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Dept. of Anatomy, Hormozgan University of Medical Sciences, Bandar-Abbas, Iran
  3. 3. Dept. of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Autonomic Neuroscience: Basic and Clinical Published:2013


Abstract

The anterior claustrum (CLa) has bilateral connections with the areas involved in cardiovascular regulation, though its role in cardiovascular control is not yet understood. This study was performed to find the cardiovascular responsive region of the CLa by stimulating all parts of the CLa with l-glutamate, and to find the possible mechanisms mediating its responses in urethane-anesthetized rats. We also investigated the possible involvement of the medial prefrontal cortex in the cardiovascular responses of the CLa. The effect of microinjection of l-glutamate (50-100. nl, 0.25. M) was tested throughout the Cla and only in one area at 2.7. mm rostral to bregma, 1.8-2.0 midline and 4.5-5.6. mm vertical, significant decreases in arterial pressure were elicited (- 21.71 ± 2.1 mmHg, P < 0.001, t-test) with no significant change in heart rate. Administration (i.v.) of the muscarinic receptor blocker, atropine, had no effect on the change in mean arterial pressure in response to glutamate stimulation, suggesting that the parasympathetic system was not involved in this response. However, administration (i.v.) of the nicotinic receptor blocker, hexamethonium dichloride abolished the depressor response to glutamate, suggesting that CLa stimulation decreases sympathetic outflow to the cardiovascular system. In addition, microinjection of the reversible synaptic blocker, cobalt chloride, into the medial prefrontal cortex greatly attenuated the depressor response elicited by microinjection of glut into the CLa. Thus for the first time, we found the cardiovascular responsive region of the anterior claustrum. Also we showed that its response is mediated through the medial prefrontal cortex. © 2013 Elsevier B.V.
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