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Bioactive Peptides: An Alternative Therapeutic Approach for Cancer Management Publisher Pubmed



Ghadiri N1 ; Javidan M1 ; Sheikhi S2 ; Tastan O3 ; Parodi A4 ; Liao Z5 ; Tayybi Azar M6 ; Ganjalikhanihakemi M2, 7
Authors
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Authors Affiliations
  1. 1. Department of Immunology, Faculty of Medicine, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran
  2. 2. Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Food Engineering, Faculty of Engineering, Yeditepe University, Istanbul, Turkey
  4. 4. Scientific Center for Translation Medicine, Sirius University of Science and Technology, Sochi, Russian Federation
  5. 5. Department of Hematology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China
  6. 6. Department of Biophysics, Faculty of Medicine, Yeditepe University, Istanbul, Turkey
  7. 7. Regenerative and Restorative Medicine Research Center (REMER), Research Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, Istanbul, Turkey

Source: Frontiers in Immunology Published:2024


Abstract

Cancer is still considered a lethal disease worldwide and the patients’ quality of life is affected by major side effects of the treatments including post-surgery complications, chemo-, and radiation therapy. Recently, new therapeutic approaches were considered globally for increasing conventional cancer therapy efficacy and decreasing the adverse effects. Bioactive peptides obtained from plant and animal sources have drawn increased attention because of their potential as complementary therapy. This review presents a contemporary examination of bioactive peptides derived from natural origins with demonstrated anticancer, ant invasion, and immunomodulation properties. For example, peptides derived from common beans, chickpeas, wheat germ, and mung beans exhibited antiproliferative and toxic effects on cancer cells, favoring cell cycle arrest and apoptosis. On the other hand, peptides from marine sources showed the potential for inhibiting tumor growth and metastasis. In this review we will discuss these data highlighting the potential befits of these approaches and the need of further investigations to fully characterize their potential in clinics. Copyright © 2024 Ghadiri, Javidan, Sheikhi, Tastan, Parodi, Liao, Tayybi Azar and Ganjalikhani-Hakemi.
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