Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
3-Oxoabolene and 1-Oxocurcuphenol, Aromatic Bisabolanes From the Sponge Myrmekioderma Sp. Publisher Pubmed



Yegdaneh A1 ; Putchakarn S2 ; Yuenyongsawad S3 ; Ghannadi A1 ; Plubrukarn A3
Authors
Show Affiliations
Authors Affiliations
  1. 1. School of Pharmacy, Isfahan University of Medical Sciences, Isfahan 81745, Iran
  2. 2. Institute of Marine Science, Burapha University, Chonburi 20131, Thailand
  3. 3. Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand

Source: Natural Product Communications Published:2013


Abstract

Two new aromatic bisabolane sesquiterpenes possessing an oxo functionality on the prenyl chain, (+)-3-oxoabolene (3) and (+)-1-oxocurcuphenol (4), along with two known sesquiterpenes, (+)-curcuphenol (1) and (+)-curcudiol (2), were isolated from the sponge Myrmekioderma sp. The antiproliferative activity of 2-4 was determined and showed an interesting selectivity; i.e., a good activity against HT-29 cells with IC50S in the μM range, but a weak and incalculable toxicity against Hela and normal fibroblast cells.