Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
A Review of Bismuth-Based Nanoparticles and Their Applications in Radiosensitising and Dose Enhancement for Cancer Radiation Therapy Publisher Pubmed



Shahbazigahrouei D1 ; Choghazardi Y1 ; Kazemzadeh A1 ; Naseri P1 ; Shahbazigahrouei S2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: IET Nanobiotechnology Published:2023


Abstract

About 50% of cancer patients receive radiation therapy. Despite the therapeutic benefits of this method, the toxicity of radiation in the normal tissues is unavoidable To improve the quality of radiation therapy, in addition to other methods such as IMRT, IGRT, and high radiation dose, nanoparticles have shown excellent potential when ionising radiation is applied to the target volume. Recently, bismuth-based nanoparticles (BiNPs) have become particularly popular in radiation therapy due to their high atomic numbers (Z), high X-ray attenuation coefficient, low toxicity, and low cost. Moreover, it is easy to synthesise in a variety of sizes and shapes. This study aimed to review the effects of the bismuth-based NP and its combination with other compounds, and their potential synergies in radiotherapy, discussed based on their physical, chemical, and biological interactions. Targeted and non-targeted bismuth-based NPs used in radiotherapy as radiosensitizers and dose enhancement effects are described. The results reported in the literature were categorised into various groups. Also, this review has highlighted the importance of bismuth-based NPs in different forms of cancer treatment to find the highest efficiency for applying them as a suitable candidate for various cancer therapy and future clinical applications. © 2023 The Authors. IET Nanobiotechnology published by John Wiley & Sons Ltd on behalf of The Institution of Engineering and Technology.
Related Docs
View other Related Docs
1. An Overview of the Intracellular Localization of High-Z Nanoradiosensitizers, Progress in Biophysics and Molecular Biology (2022)
2. Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review, Diagnostics (2023)
3. Assessment of Oxaliplatin-Loaded Iodine Nanoparticles for Chemoradiotherapy of Human Colorectal Cancer (Ht-29) Cells, Polymers (2022)
4. Bioavailability, Biodistribution, and Toxicity of Fluorescent Metal Nanoclusters, Luminescent Metal Nanoclusters: Synthesis, Characterization, and Applications (2022)
5. A Review on Theranostic Applications of Iodine Nanoparticles: Recent Findings and Perspectives, Nanomedicine Journal (2021)
6. Trastuzumab and Folic Acid Functionalized Gold Nanoclusters As a Dual-Targeted Radiosensitizer for Megavoltage Radiation Therapy of Human Breast Cancer, European Journal of Pharmaceutical Sciences (2020)
7. Radioprotective Effect of Selenium Nanoparticles: A Mini Review, IET Nanobiotechnology (2024)
8. Recent Nanotheranostics Applications for Cancer Therapy and Diagnosis: A Review, IET Nanobiotechnology (2021)
Experts (# of related papers)
View all Related Experts
Daryoush Shahbazi-Gahrouei (13)
Jaleh Varshosaz (6)
Other Related Docs
9. Modified Bismuth Nanoparticles: A New Targeted Nanoprobe for Computed Tomography Imaging of Cancer, Cell Journal (2022)
10. High-Performance Spirulina-Bismuth Biohybrids for Enhanced Computed Tomography Imaging, ACS Sustainable Chemistry and Engineering (2020)
11. Investigation of Combination Effect Between 6 Mv X-Ray Radiation and Polyglycerol Coated Superparamagnetic Iron Oxide Nanoparticles on U87-Mg Cancer Cells, Journal of Biomedical Physics and Engineering (2020)
12. As1411 Aptamer-Targeted Gold Nanoclusters Effect on the Enhancement of Radiation Therapy Efficacy in Breast Tumor-Bearing Mice, Nanomedicine (2018)
13. Chitosan–Imidazolium Core–Shell Nanoparticles of Gd-Mn-Mo Polyoxometalate As Novel Potential Mri Nano-Agent for Breast Cancer Detection, Micromachines (2023)
14. A Concise Review on Cancer Treatment Methods and Delivery Systems, Journal of Drug Delivery Science and Technology (2019)
15. The Role of Folic Acid-Conjugated Polyglycerol Coated Iron Oxide Nanoparticles on Radiosensitivity With Clinical Electron Beam (6 Mev) on Human Cervical Carcinoma Cell Line: In Vitro Study, Journal of Photochemistry and Photobiology B: Biology (2018)
16. Investigation of Different Targeting Decorations Effect on the Radiosensitizing Efficacy of Albumin-Stabilized Gold Nanoparticles for Breast Cancer Radiation Therapy, European Journal of Pharmaceutical Sciences (2019)
17. Efficacy of Co-Immunization With the Dna and Peptide Vaccines Containing Sycp1 and Acrbp Epitopes in a Murine Triple-Negative Breast Cancer Model, Human Vaccines and Immunotherapeutics (2021)
18. Optimal Scheduling of the Nanoparticle-Mediated Cancer Photo-Thermo-Radiotherapy, Photodiagnosis and Photodynamic Therapy (2020)
19. Arsenic Polyoxotungstate-Zeolitic Imidazolate Framework-8 As a Potential Selective Anti-Cancer Nano Platform, Journal of Inorganic and Organometallic Polymers and Materials (2023)
20. Biodegradable and Biocompatible Subcutaneous Implants Consisted of Ph-Sensitive Mebendazole-Loaded/Folic Acid-Targeted Chitosan Nanoparticles for Murine Triple-Negative Breast Cancer Treatment, Journal of Nanobiotechnology (2022)
21. Co-Delivery of Carboplatin and Doxorubicin Using Zif-8 Coated Chitosan-Poly(N-Isopropyl Acrylamide) Nanoparticles Through a Dual Ph/Thermo Responsive Strategy to Breast Cancer Cells, International Journal of Biological Macromolecules (2024)
22. As1411 Aptamer Conjugated Gold Nanoclusters As a Targeted Radiosensitizer for Megavoltage Radiation Therapy of 4T1 Breast Cancer Cells, RSC Advances (2018)
23. Advances in Aptamer-Based Drug Delivery Vehicles for Cancer Therapy, Biomaterials Advances (2022)
24. A Literature Review on Multimodality Molecular Imaging Nanoprobes for Cancer Detection, Polish Journal of Medical Physics and Engineering (2019)
25. Biosynthesis of Bismuth Nanoparticles Using Serratia Marcescens Isolated From the Caspian Sea and Their Characterisation, IET Nanobiotechnology (2012)
26. Exploring the Cancer-Testis Antigen Boris to Design a Novel Multi-Epitope Vaccine Against Breast Cancer Based on Immunoinformatics Approaches, Journal of Biomolecular Structure and Dynamics (2022)
27. Doxorubicin-Loaded Pvp Coated Gd2o3 Nps for Effective Chemoradiotherapy in Melanoma, Journal of Drug Delivery Science and Technology (2019)
28. Aptamer-Conjugated Magnetic Nanoparticles As Targeted Magnetic Resonance Imaging Contrast Agent for Breast Cancer, Journal of Medical Signals and Sensors (2016)
29. Gold Nanoparticles in Combination With Megavoltage Radiation Energy Increased Radiosensitization and Apoptosis in Colon Cancer Ht-29 Cells, International Journal of Radiation Biology (2017)
30. Effect of Targeted Gold Nanoparticles Size on Acoustic Cavitation: An in Vitro Study on Melanoma Cells, Ultrasonics (2020)
31. Polymeric Nanoparticles in Cancer Chemotherapy: A Narrative Review, Iranian Journal of Public Health (2022)
32. Boron Neutron Capture Therapy: Moving Toward Targeted Cancer Therapy, Journal of Cancer Research and Therapeutics (2016)
33. Medical Imaging Modalities Using Nanoprobes for Cancer Diagnosis: A Literature Review on Recent Findings, Journal of Research in Medical Sciences (2019)
34. Encapsulation of Imatinib in Targeted Kit-5 Nanoparticles for Reducing Its Cardiotoxicity and Hepatotoxicity, Anti-Cancer Agents in Medicinal Chemistry (2020)
35. In Vitro Investigation of Radiotherapy Along With Gemcitabine Loaded Peg Gold Nanoparticles Against Mcf-7 Breast Cancer Cells, Advanced Biomedical Research (2025)
36. Sodium-Borohydride Exfoliated Bismuthene Loaded With Mitomycin C for Chemo-Photo-Radiotherapy of Triple Negative Breast Cancer, International Journal of Pharmaceutics (2023)