Juvenile-Onset Mixed Connective Tissue Disease Associated With Macrophage Activation Syndrome: A Case With Refractory Raynaud's Phenomenon

Juvenile-Onset Mixed Connective Tissue Disease Associated With Macrophage Activation Syndrome: A Case With Refractory Raynaud's Phenomenon Publisher

Parvaneh VJ¹ ; Jari M^{1, 2} ; Ghasemi S³ ; Rahmani K¹ ; Shiari R¹

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1. Department of Pediatric Rheumatology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Department of Pediatrics, Imam Hossein children's Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
3. Department of Pediatrics, Ali-asghar Children's Hospital, Iran University of Medical Sciences, Tehran, Iran

Source: Egyptian Rheumatologist Published:2019

Abstract

Introduction: Mixed connective tissue disease (MCTD) is an autoimmune disease that is rare in children. The disease is presented with complex clinical features, so early diagnosis is challenging. Herein we describe the management and outcome of a girl with MCTD associated with macrophage activation syndrome (MAS) and refractory Raynauds’ phenomenon. Case report: A 13-year-old girl was admitted to the pediatric rheumatology ward with mild fever, reduced appetite, 6 kg weight loss (body mass index 15.8), digital ulcers, sclerodactyly, scleroderma, dysphagia, gastroesophageal reflux and arthralgia. She also had photosensitivity, Raynaud's phenomenon, painless oral ulcers, and malar rash. She developed arthritis of the knees and ankles with limited range of motion. Spirometry showed a restrictive pattern. There was speckled antinuclear antibodies (ANA; 1/1260) and positive β-2-glycoprotein, U1-ribonucleoprotein (U1-RNP), anti-Scl-70 and anti-Ro52 antibodies. Anti-double stranded deoxyribonucleic acid and anti-cyclic citrullinated protein antibodies were negative. Based on clinical and laboratory findings, MCTD was confirmed. The child was treated with steroid, vasodilators, and immunosuppressives. She had an attack of salmon pink rashes, spiky fevers, Koebner phenomenon, serositis, and organomegaly and the diagnosis of associated MAS was held. The patient was treated with pentoxifylline, prednisolone, methotrexate, low dose aspirin, nifedipine, and hydroxychloroquine. On follow up there was refractory digital ulcers and Raynaud's phenomenon; transthoracic endoscopic sympathectomy was performed and digital ulcers and coldness resolved. Conclusion: MCTD may present with a myriad of rheumatic manifestations and in association with MAS the diagnosis and management may be challenging. Refractory Raynauds’ phenomenon may remarkably improve on transthoracic sympathectomy. © 2019

Style	Citing Format
MLA	Parvaneh VJ, et al.. "Juvenile-Onset Mixed Connective Tissue Disease Associated With Macrophage Activation Syndrome: A Case With Refractory Raynaud's Phenomenon." Egyptian Rheumatologist, vol. 41, no. 4, 2019, pp. 323-325.
APA	Parvaneh VJ, Jari M, Ghasemi S, Rahmani K, Shiari R (2019). Juvenile-Onset Mixed Connective Tissue Disease Associated With Macrophage Activation Syndrome: A Case With Refractory Raynaud's Phenomenon. Egyptian Rheumatologist, 41(4), 323-325.
Chicago	Parvaneh VJ, Jari M, Ghasemi S, Rahmani K, Shiari R. "Juvenile-Onset Mixed Connective Tissue Disease Associated With Macrophage Activation Syndrome: A Case With Refractory Raynaud's Phenomenon." Egyptian Rheumatologist 41, no. 4 (2019): 323-325.
Harvard	Parvaneh VJ et al. (2019) 'Juvenile-Onset Mixed Connective Tissue Disease Associated With Macrophage Activation Syndrome: A Case With Refractory Raynaud's Phenomenon', Egyptian Rheumatologist, 41(4), pp. 323-325.
Vancouver	Parvaneh VJ, Jari M, Ghasemi S, Rahmani K, Shiari R. Juvenile-Onset Mixed Connective Tissue Disease Associated With Macrophage Activation Syndrome: A Case With Refractory Raynaud's Phenomenon. Egyptian Rheumatologist. 2019;41(4):323-325.
BibTex	@article{ author = {Parvaneh VJ and Jari M and Ghasemi S and Rahmani K and Shiari R}, title = {Juvenile-Onset Mixed Connective Tissue Disease Associated With Macrophage Activation Syndrome: A Case With Refractory Raynaud's Phenomenon}, journal = {Egyptian Rheumatologist}, volume = {41}, number = {4}, pages = {323-325}, year = {2019} }
RIS	TY - JOUR AU - Parvaneh VJ AU - Jari M AU - Ghasemi S AU - Rahmani K AU - Shiari R TI - Juvenile-Onset Mixed Connective Tissue Disease Associated With Macrophage Activation Syndrome: A Case With Refractory Raynaud's Phenomenon JO - Egyptian Rheumatologist VL - 41 IS - 4 SP - 323 EP - 325 PY - 2019 ER -

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