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Genotoxicity and Micronucleus Formation As a Result of Panoramic Radiography in Epithelial Cells of the Buccal Mucosa: A Cross-Sectional Study in Adults Publisher Pubmed



Torabinia N1 ; Mehdizadeh M2 ; Keshani F3 ; Mehdizadeh M2 ; Soltani P2, 5 ; Spagnuolo G5
Authors
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Authors Affiliations
  1. 1. Department of Oral and Maxillofacial Pathology, Dental Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Oral and Maxillofacial Radiology, Dental Implants Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Oral and Maxillofacial Pathology, Dental Materials Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Students Research Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, Naples, Italy

Source: Clinical and Experimental Dental Research Published:2024


Abstract

Objectives: To determine the genetic effects of panoramic radiography on the epithelial cells of the buccal mucosa by examining the micronucleus formation in these cells. Materials and Methods: In this cross-sectional study, exfoliative cytology samples were prepared from the buccal mucosa of 36 patients immediately before and 10 days after panoramic radiography. The samples were prepared using liquid-based cytology with Papanicolaou staining. The slides were simultaneously evaluated by two expert pathologists and the ratio of the number of cells with micronuclei to the total number of cells on the slide was reported as a percentage. Data analysis was done using paired-samples T test, Pearson's correlation coefficient, and covariance analysis (α = 0.05). Results: The study sample consisted of 24 (66.67%) males and 12 females (33.33%) with a mean (SD) age of 27.36 (8.19) years. The frequency of cells with micronucleus before and after panoramic radiography was not statistically different (p = 0.468). Additionally, the frequency of micronucleated cells was not correlated with age (p = 0.737) and sex (p = 0.211). Conclusion: Panoramic exposure slightly increased the frequency of cells with micronucleus in epithelial cells of the buccal mucosa. However, this increase was not statistically significant. © 2024 The Author(s). Clinical and Experimental Dental Research published by John Wiley & Sons Ltd.
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