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Predictors of Continued Use of Extended-Released Naltrexone (Xr-Ntx) for Opioid-Dependence: An Analysis of Heroin and Non-Heroin Opioid Users in Los Angeles County Publisher Pubmed



Cousins SJ1 ; Radfar SR1, 2 ; Crevecoeurmacphail D1 ; Ang A1 ; Darfler K1 ; Rawson RA1
Authors
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Authors Affiliations
  1. 1. University of California, Los Angeles, Integrated Substance Abuse Programs, 11075 Santa Monica Blvd., Suite 200, Los Angeles, 90025, CA, United States
  2. 2. Isfahan University of Medical Science, Hezar Jerib Avenue, Isfahan, 81745, Iran

Source: Journal of Substance Abuse Treatment Published:2016


Abstract

Extended-release naltrexone (XR-NTX) is associated with an increased number of opioid-free days, improved adherence rates in substance use disorder treatment programs, and reduced cravings and drug-seeking behaviors. There is little evidence on the predictive associations between baseline characteristics of opioid-dependent patients and XR-NTX utilization. Some studies have demonstrated better pharmacotherapy adherence and/or retention rates among non-heroin opioid users compared to heroin users. This study examines predictive associations between characteristics of patients and XR-NTX utilization, as well as participants' urge to use opiates. Our findings suggest that XR-NTX may contribute to decreases in urges to use among both heroin and non-heroin opioid users. Non-heroin opioid users and heroin users were retained in XR-NTX treatment for comparable periods of time. However, those who identified as homeless, injected opioids (regardless of opioid-type), or were diagnosed with a mental illness were less likely to be retained in treatment with XR-NTX. © 2015 Elsevier Inc.
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