Synthesis of Some New 2,3-Disubstituted-4(3H)Quinazolinone Derivatives



Hassanzadeh F¹ ; Rahmani Khajouei M¹ ; Hakimelahi GH^{1, 2} ; Jafari E¹ ; Khodarahmi GA¹
Source: Research in Pharmaceutical Sciences Published:2012

Abstract

Quinazolinones are interesting materials because of their valuable biological effects. In this study some new 2,3-disubstituted-4(3H)quinqzolinone derivatives were synthesized from anthranilic acid in six steps by introducing a new chiral center to the aliphatic side chain of the quinazolinone. In the last step, a single acylation on the hydrazine moiety afforded final compounds. The structures of compounds were confirmed by IR, 1HNMR and Mass spectra.