Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Synthesis of Some New 2,3-Disubstituted-4(3H)Quinazolinone Derivatives



Hassanzadeh F1 ; Rahmani Khajouei M1 ; Hakimelahi GH1, 2 ; Jafari E1 ; Khodarahmi GA1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Science, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Institute of Chemistry, Academia Sinica, Nankang, Taipei, Taiwan

Source: Research in Pharmaceutical Sciences Published:2012

Abstract

Quinazolinones are interesting materials because of their valuable biological effects. In this study some new 2,3-disubstituted-4(3H)quinqzolinone derivatives were synthesized from anthranilic acid in six steps by introducing a new chiral center to the aliphatic side chain of the quinazolinone. In the last step, a single acylation on the hydrazine moiety afforded final compounds. The structures of compounds were confirmed by IR, 1HNMR and Mass spectra.
Related Docs
View other Related Docs
1. Synthesis and Cytotoxic Evaluation of Some New 3-(2-(2-Phenylthiazol-4-Yl) Ethyl)-Quinazolin-4(3H) One Derivatives With Potential Anticancer Effects, Research in Pharmaceutical Sciences (2017)
2. Synthesis and Cytotoxicity Evaluation of Some New 6-Nitro Derivatives of Thiazole-Containing 4-(3H)-Quinazolinone, Research in Pharmaceutical Sciences (2016)
3. Synthesis of Some New Tricyclic 4(3H)-Quinazolinone Derivatives, Research in Pharmaceutical Sciences (2011)
4. Quinazolinone and Quinazoline Derivatives: Recent Structures With Potent Antimicrobial and Cytotoxic Activities, Research in Pharmaceutical Sciences (2016)
5. Synthesis and Cytotoxic Evaluation of Some New 4(3H)-Quinazolinones on Hela Cell Line, Research in Pharmaceutical Sciences (2012)
6. Antibacterial, Antifungal and Cytotoxic Evaluation of Some New 2,3-Disubstituted 4(3H)-Quinazolinone Derivatives, Research in Pharmaceutical Sciences (2012)
7. Synthesis and Cytotoxic Evaluation of Some Quinazolinone- 5-(4-Chlorophenyl) 1, 3, 4-Oxadiazole Conjugates, Research in Pharmaceutical Sciences (2019)
8. Synthesis and Cytotoxic Evaluation of Some Derivatives of Triazole-Quinazolinone Hybrids, Research in Pharmaceutical Sciences (2019)
Experts (# of related papers)
View all Related Experts
Farshid Hassanzadeh (13)
Ghadamali Khodarahmi (10)
Other Related Docs
9. Quinazolinone-Based Hybrids With Diverse Biological Activities: A Mini-Review, Journal of Research in Medical Sciences (2022)
10. Synthesis, Characterization, Cytotoxic Screening, and Density Functional Theory Studies of New Derivatives of Quinazolin-4(3H)-One Schiff Bases, Research in Pharmaceutical Sciences (2017)
11. Docking and Qsar Studies of Some Quinazolinone Derivatives As Possible Inhibitors of Thyrosine Kinase, Turkish Computational and Theoretical Chemistry (2022)
12. Antibacterial, Antifungal and Cytotoxic Evaluation of Some New Quinazolinone Derivatives, Research in Pharmaceutical Sciences (2012)
13. Synthesis and Antimicrobial Evaluation of Some 2,5 Disubstituted 1,3,4-Oxadiazole Derivatives, Research in Pharmaceutical Sciences (2017)
14. Biologically Active Heterocyclic Hybrids Based on Quinazolinone, Benzofuran and Imidazolium Moieties: Synthesis, Characterization, Cytotoxic and Antibacterial Evaluation, Chemistry and Biodiversity (2017)
15. Synthesis and Cytotoxic Evaluation of Novel Quinozalinone Derivatives With Substituted Benzimidazole in Position 3, Research in Pharmaceutical Sciences (2019)
16. Synthesis, Antimicrobial Evaluation and Docking Studies of Some Novel Quinazolinone Schiff Base Derivatives, Research in Pharmaceutical Sciences (2018)
17. Synthesis, Spectroscopic Characterization, Antimicrobial Evaluation and Molecular Docking Study of Novel Triazine-Quinazolinone Based Hybrids, Journal of Molecular Structure (2018)
18. Synthesis and Antifungal Activity Evaluation of a Fluconazole Analog Derived From Dithiocarbamate, Journal of Mazandaran University of Medical Sciences (2024)
19. Synthesis, Characterization, Molecular Docking Studies and Biological Evaluation of Some Novel Hybrids Based on Quinazolinone, Benzofuran and Imidazolium Moieties As Potential Cytotoxic and Antimicrobial Agents, Iranian Journal of Basic Medical Sciences (2017)