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Granulomatous Interstitial Nephritis As a Manifestation of Crohn Disease Publisher



Colvin RB1 ; Traum AZ2 ; Taheri D1, 3, 4 ; Jafari M4 ; Dolatkhah S5
Authors
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Authors Affiliations
  1. 1. Department of Pathology, Massachusetts General Hospital, Harvard Medical School, United States
  2. 2. Department of Nephrology, Massachusetts General Hospital, Harvard Medical School, United States
  3. 3. Isfahan Kidney Diseases Research Center, Department of Pathology, Isfahan University of Medical Sciences, Isfahan 8168788131, Iran
  4. 4. Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Archives of Pathology and Laboratory Medicine Published:2014


Abstract

Granulomatous interstitial nephritis is a rare extraintestinal manifestation of Crohn disease that has been described previously in 4 patients. We report a 23-yearold man with a history of Crohn disease since age 6 years who was admitted to the hospital for weight loss, fever, and bloody diarrhea in the midst of a recent flare up during the past 2 months. Investigations revealed anemia, high erythrocyte sedimentation rate, high C-reactive protein level, and an elevated serum creatinine level. Histopathologic examination of tissue specimens obtained at renal biopsy demonstrated granulomatous interstitial nephritis. Crohn disease needs to be in the differential diagnosis of granulomatous interstitial nephritis and can be a manifestation of drug allergy or the Crohn disease itself. Copyright © 2014 College of American Pathologists.
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