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Effects of Selenium Supplementation on Expression of Sepp1 in Mrna and Protein Levels in Subjects With and Without Metabolic Syndrome Suffering From Coronary Artery Disease: Selenegene Study a Double-Blind Randomized Controlled Trial Publisher Pubmed



Gharipour M1 ; Ouguerram K2 ; Nazih EH3 ; Salehi M4 ; Behmanesh M5 ; Roohafza H6 ; Hosseini SM7 ; Nezafati P8 ; Dianatkhah M9 ; Gharipour A10 ; Haghjoo S11 ; Sarrafzadegan N9 ; Sadeghi M8
Authors
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Authors Affiliations
  1. 1. Division of Genetic Studies, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medicine Sciences, Isfahan, Iran
  2. 2. UMR PHAN, INRA, and Universite de Nantes, IMAD, CRNH-Ouest, Nantes, France
  3. 3. Faculte de Pharmacie, EA 2160 MMS - Institut Universitaire Mer et Littoral FR3473 CNRS, Centre de Recherche en Nutrition Humaine Ouest (CRNH Ouest), ULB Universite de Nantes, Nantes, France
  4. 4. Department of Genetics and Molecular Biology Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  6. 6. Psychosomatic Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  9. 9. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medicine Sciences, Isfahan, Iran
  10. 10. Griffith University, School of Information and Communication Technology, Gold Coast Campus, Australia
  11. 11. Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Cellular Biochemistry Published:2018


Abstract

Selenoprotein P (SePP) is involved in the protection against diseases. The present study is the first investigation of the effect of selenium supplementation on plasma selenium and expression of SEPP1 in mRNA and protein levels based on metabolic syndrome (MetS), in individuals suffering from coronary artery diseases. In this clinical trial, 160 patients with angiographically documented stenosis of more than 75% in each vessel were enrolled. Patients received either 200-mg selenium yeast tablets or placebo tablets orally after a meal, once daily for 60 days. The mRNA and protein levels of the selenium and SePP1 products were determined before and after the study. From the initial 160 participants, 145 subjects (71 MetS-affected individuals, 74 MetS-unaffected individuals) enrolled in this study. Comparing the selenium and placebo groups, no significant percentage changes of plasma selenium, △Ct SEPP1, or SePP were shown (P > 0.05). Moreover, beyond a significant difference for the expression of SePP in the selenium group compared to its baseline level (P < 0.05), no other significant differences were revealed for plasma selenium and △Ct SEPP1 after the intervention in either group (P > 0.05). Selenium supplementation did not affect plasma selenium or the mRNA or protein level of SePP in either groups after a 2-months intervention beyond a significant increase of SePP in the MetS group. This trial suggests that further studies should investigate the long-term use of selenium supplementation and the effect of a SePP increase on MetS as a potential therapeutic effect. © 2018 Wiley Periodicals, Inc.
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