Evaluating the Effect of Intravenous Haloperidol and Midazolam on Postoperative Nausea and Vomiting After Strabismus Surgery



Aghadavoudi O¹ ; Mirkheshti M² Show Affiliations
Source: Journal of Isfahan Medical School Published:2014

Abstract

Background: Usage of midazolam and haloperidol for prevention of postoperative nausea and vomiting has been considered before. Purpose of this study was to evaluate the anti-emetic effect of combination of haloperidol with midazolam on postoperative nausea and vomiting in patients underwent strabismus surgery. Methods: In this randomized, double-blind, placebo-controlled study, 90 patients with the age of 18-60 years underwent general anesthesia for strabismus surgery in Feiz hospital, Isfahan, Iran, were divided into 3 groups of 30. Group A received 0.05 mg/kg of midazolam, group B received 0.05 mg/kg of midazolam plus 0.05 mg/kg of haloperidol, and group C was the control group. The incidence of postoperative nausea and vomiting were evaluated in post-anesthesia care unit and ward. Findings: Making a comparison, the incidence of postoperative nausea and vomiting in group B was significantly lower than groups A and C (P < 0.05 for both). The lowest incidence of postoperative nausea and vomiting happened in group B, where the postoperative anti-emetic need was significantly lower than groups A and C (P < 0.05 for both). Conclusion: Administration of 0.05 mg/kg of haloperidol plus 0.05 mg/kg of midazolam reduces the postoperative nausea and vomiting more than midazolam alone in patients undergo strabismus surgery.