Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Cisplatin-Induced Nephrotoxicity; Protective Supplements and Gender Differences Publisher



Nematbakhsh M1 ; Pezeshki Z1 ; Jazi FE1 ; Mazaheri B1 ; Moeini M1 ; Safari T1 ; Azarkish F1 ; Moslemi F1 ; Maleki M1 ; Rezaei A1 ; Saberi S1 ; Dehghani A1 ; Malek M1 ; Mansouri A1 Show All Authors
Authors
  1. Nematbakhsh M1
  2. Pezeshki Z1
  3. Jazi FE1
  4. Mazaheri B1
  5. Moeini M1
  6. Safari T1
  7. Azarkish F1
  8. Moslemi F1
  9. Maleki M1
  10. Rezaei A1
  11. Saberi S1
  12. Dehghani A1
  13. Malek M1
  14. Mansouri A1
  15. Ghasemi M1
  16. Zeinali F1
  17. Zamani Z1
  18. Navidi M1
  19. Jilanchi S1
  20. Shirdavani S1
  21. Ashrafi F1
Show Affiliations
Authors Affiliations
  1. 1. Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Asian Pacific Journal of Cancer Prevention Published:2017


Abstract

Cisplatin (CDDP) has been widely used as a chemotherapeutic agent for solid tumors. The most common side effect of CDDP is nephrotoxicity, and many efforts have been made in the laboratory and the clinic to employ candidate adjuvants to CDDP to minimize this adverse influence. Many synthetic and herbal antioxidants as well as trace elements have been investigated for this purpose in recent years and a variety of positive and negative results have been yielded. However, no definitive supplement has so far been proposed to prevent CDDP-induced nephrotoxicity; however, this condition is gender related and the sex hormone estrogen may protect the kidney against CDDP damage. In this review, the results of research related to the effect of different synthetic and herbal antioxidants supplements are presented and discussed with suggestions included for future work.
Other Related Docs
22. Age and Gender Related Renal Side Effects of Cisplatin in Animal Model, Asian Pacific Journal of Cancer Prevention (2017)
24. Effect of Short Hydration on Cisplatin-Induced Nephrotoxicity in Cancer Patients: A Retrospective Study, International Journal of Hematology-Oncology and Stem Cell Research (2017)
35. Cisplatin-Induced Renal Toxicity: A Short Review, Life Science Journal (2014)
50. Cisplatin Nephrotoxicity May Be Sex Related, Kidney International (2013)