The Effect of L-Carnitine Supplementation on Serum Levels of Omentin-1, Visfatin and Sfrp5 and Glycemic Indices in Patients With Pemphigus Vulgaris: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Publisher Pubmed



Sepandar F¹ ; Daneshpazhooh M² ; Djalali M¹ ; Mohammadi H⁶ ; Yaghubi E¹ ; Fakhri Z¹ ; Tavakoli H¹ ; Ghaedi E¹ ; Keshavarz A³ ; Zarei M¹ ; Shahrbaf MA⁴ ; Ghandi N² ; Darand M⁵ ; Javanbakht MH¹
Source: Phytotherapy Research Published:2020

Abstract

Pemphigus vulgaris (PV) is a chronic autoimmune disorder with potentially fatal outcomes. The aim of this study was to investigate the effect of l-carnitine (LC) on secreted frizzled-related protein-5 (SFRP5), omentin, visfatin, and glycemic indices in PV patients under corticosteroid treatment. In this randomized, double-blind, placebo-controlled clinical trial, 52 patients with PV were divided randomly into two groups to receive 2 g of LC or a placebo for 8 weeks. Serum levels of SFRP5, omentin, visfatin, and also glycemic indices were evaluated at the baseline and end of the study. LC supplementation significantly decreased the serum level of visfatin (95% CI [−14.718, −0.877], p =.05) and increased the serum levels of SFRP5 (95%CI [1.637, 11.380], p <.006) and omentin (95% CI [9.014, 65.286], p <.01). However, LC supplementation had no significant effects on the serum levels of glycemic factors such as insulin (95% CI [−1.125, 3.056], p =.426), fasting blood sugar (95% CI [−4.743, 3.642], p =.894), homeostatic model assessment of insulin resistance (95% CI [−0.305, 0.528], p =.729), and quantitative insulin-sensitivity check index (95% CI [−0.016, −0.010], p =.81). LC supplementation decreased visfatin serum level and increased omentin-1 and SFRP5 serum levels in patients with PV. However, it has no significant effect on the serum levels of insulin and glycemic indices. © 2019 John Wiley & Sons, Ltd.