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Evaluation of the Prevalence of Anti-Transglutaminase 2 and 6 Antibodies in Patients With Sero-Positive Multiple Sclerosis Publisher



Emami MH1 ; Najafi MR3 ; Allahdadian S5 ; Mohammadzadeh S1, 2 ; Jamali N6 ; Lalazarian A1, 2 ; Shaygan Nejad V3, 4 ; Maghool F1, 2
Authors
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Authors Affiliations
  1. 1. Poursina Hakim Digestive Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Pooya Zist-Mabna Hakim Company, Poursina Hakim Institute, Isfahan, Iran
  3. 3. Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Isfahan Neurosciences Research Centre (INRC), Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Neurology, Penn State Milton S. Hershey Medical Center, Hershey, PA, United States
  6. 6. Department of Health Policy, School of Management and Information, Iran University of Medical Sciences, Tehran, Iran

Source: Middle East Journal of Digestive Diseases Published:2024


Abstract

Background: Gluten sensitivity (GS) is one of the gluten-related disorders (GRDs). Patients with GS may have serum antibodies against tissue transglutaminase (tTG) (IgA and IgG) without any evidence of enteropathy. We aimed to evaluate both tTG-6 and tTG-2 antibodies to determine the prevalence of seropositive tTG-2 and tTG-6 antibodies in patients with multiple sclerosis (MS). Methods: In this cross-sectional study, we carried out serological tests (IgA & IgG anti-tTG-6 and tTG-2 antibodies) in patients with MS. Results: Seventy-two patients with MS were included in this study. Of them, seropositive patients for total (IgA+IgG) of tTG-6 and tTG-2 autoantibodies were 9.7% (95% CI, 4.2-18) and 5.6% (95% CI, 1.4-12.5), respectively. Conclusion: Anti-tTG-6 antibody testing may be necessary for early diagnosis of GS in patients with MS. More studies with larger sample sizes are warranted to confirm these data. © 2024 The Author(s).
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