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Comparison of Macular Octs in Right and Left Eyes of Normal People Publisher



Mahmudi T1 ; Kafieh R1 ; Rabbani H1 ; Mehri Dehnavi A1 ; Akhlagi M2
Authors
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Authors Affiliations
  1. 1. Department of Advanced Medical Technologies, Medical Image and Signal Processing Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Ophthalmology Dept., School of Medicine, Isfahan Univ. of Medical Sciences, Isfahan, Iran

Source: Progress in Biomedical Optics and Imaging - Proceedings of SPIE Published:2014


Abstract

Retinal 3D Optical coherence tomography (OCT) is a non-invasive imaging modality in ocular diseases. Due to large volumes of OCT data, it is better to utilize automatic extraction of information from OCT images, such as total retinal thickness and retinal nerve fiber layer thickness (RNFLT). These two thickness values have become useful indices to indicate the progress of diseases like glaucoma, according to the asymmetry between two eyes of an individual. Furthermore, the loss of ganglion cells may not be diagnosable by other tests and even not be evaluated when we only consider the thickness of one eye (due to dramatic different thickness among individuals). This can justify our need to have a comparison between thicknesses of two eyes in symmetricity. Therefore, we have proposed an asymmetry analysis of the retinal nerve layer thickness and total retinal thickness around the macula in the normal Iranian population. In the first step retinal borders are segmented by diffusion map method and thickness profiles were made. Then we found the middle point of the macula by pattern matching scheme. RNFLT and retinal thickness are analyzed in 9 sectors and the mean and standard deviation of each sector in the right and left eye are obtained. The maximums of the average RNFL thickness in right and left eyes are seen in the perifoveal nasal, and the minimums are seen in the fovea. Tolerance limits in RNFL thickness is shown to be between 0.78 to 2.4 μm for 19 volunteers used in this study. © 2014 SPIE.
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