Insights Into the Development of 99Mtc-Radioligands for Serotonergic Receptors Imaging: Synthesis, Labeling, in Vitro, and in Vivo Studies

Insights Into the Development of 99Mtc-Radioligands for Serotonergic Receptors Imaging: Synthesis, Labeling, in Vitro, and in Vivo Studies Publisher Pubmed

Saednia S^{1, 4} ; Emami S² ; Moslehi M³ ; Hosseinimehr SJ⁴

Show Affiliations

1. Farabi Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
2. Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
3. Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4. Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

Source: European Journal of Medicinal Chemistry Published:2024

Abstract

Serotonergic (5-hydroxytryptamine; 5-HT) receptors play critical roles in neurological and psychological disorders such as schizophrenia, anxiety, depression, and Alzheimer's diseases. Therefore, it is particularly important to develop novel radioligands or modify the existing ones to identify the serotonergic receptors involved in psychiatric disorders. Among the 16 subtypes of serotonergic systems, only technetium-99m based radiopharmaceuticals have been evaluated for serotonin-1A (5-HT1A), serotonin-2A (5-HT2A), 5-HT1A/7 heterodimers and serotonin receptor neurotransmitter (SERT). This review focuses on recent efforts in the design, synthesis and evaluation of 99mTc-radioligands used for single photon emission computerized tomography (SPECT) imaging of serotonergic (5-HT) receptors. Additionally, the discussion will cover aspects such as chemical structure, in vitro/vivo stability, affinity toward serotonin receptors, blood-brain barrier permeation (BBB), and biodistribution study. © 2024 Elsevier Masson SAS

Style	Citing Format
MLA	Saednia S, et al.. "Insights Into the Development of 99Mtc-Radioligands for Serotonergic Receptors Imaging: Synthesis, Labeling, in Vitro, and in Vivo Studies." European Journal of Medicinal Chemistry, vol. 270, no. , 2024, pp. -.
APA	Saednia S, Emami S, Moslehi M, Hosseinimehr SJ (2024). Insights Into the Development of 99Mtc-Radioligands for Serotonergic Receptors Imaging: Synthesis, Labeling, in Vitro, and in Vivo Studies. European Journal of Medicinal Chemistry, 270(), -.
Chicago	Saednia S, Emami S, Moslehi M, Hosseinimehr SJ. "Insights Into the Development of 99Mtc-Radioligands for Serotonergic Receptors Imaging: Synthesis, Labeling, in Vitro, and in Vivo Studies." European Journal of Medicinal Chemistry 270, no. (2024): -.
Harvard	Saednia S et al. (2024) 'Insights Into the Development of 99Mtc-Radioligands for Serotonergic Receptors Imaging: Synthesis, Labeling, in Vitro, and in Vivo Studies', European Journal of Medicinal Chemistry, 270(), pp. -.
Vancouver	Saednia S, Emami S, Moslehi M, Hosseinimehr SJ. Insights Into the Development of 99Mtc-Radioligands for Serotonergic Receptors Imaging: Synthesis, Labeling, in Vitro, and in Vivo Studies. European Journal of Medicinal Chemistry. 2024;270():-.
BibTex	@article{ author = {Saednia S and Emami S and Moslehi M and Hosseinimehr SJ}, title = {Insights Into the Development of 99Mtc-Radioligands for Serotonergic Receptors Imaging: Synthesis, Labeling, in Vitro, and in Vivo Studies}, journal = {European Journal of Medicinal Chemistry}, volume = {270}, number = {}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Saednia S AU - Emami S AU - Moslehi M AU - Hosseinimehr SJ TI - Insights Into the Development of 99Mtc-Radioligands for Serotonergic Receptors Imaging: Synthesis, Labeling, in Vitro, and in Vivo Studies JO - European Journal of Medicinal Chemistry VL - 270 IS - SP - EP - PY - 2024 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract