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Covid-19 Vaccination in Patients With Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to Covid-19: A Usidnet Report Publisher Pubmed



Mcdonnell J1 ; Cousins K2 ; Younger MEM136 ; Lane A3, 4 ; Abolhassani H5, 6 ; Abraham RS7, 8 ; Altamemi S9 ; Aldavebecerra JC10 ; Alfaris EH11 ; Alfaromurillo A12 ; Alkhater SA13, 14 ; Alsaati N15 ; Doss AMA16 ; Anderson M17 Show All Authors
Authors
  1. Mcdonnell J1
  2. Cousins K2
  3. Younger MEM136
  4. Lane A3, 4
  5. Abolhassani H5, 6
  6. Abraham RS7, 8
  7. Altamemi S9
  8. Aldavebecerra JC10
  9. Alfaris EH11
  10. Alfaromurillo A12
  11. Alkhater SA13, 14
  12. Alsaati N15
  13. Doss AMA16
  14. Anderson M17
  15. Angarola E18
  16. Ariue B19
  17. Arnold DE20
  18. Assaad AH21
  19. Aytekin C22
  20. Bank M23
  21. Bergerson JRE24
  22. Bleesing J3, 4
  23. Boesing J25
  24. Bouso C26
  25. Brodszki N27
  26. Cabanillas D28
  27. Cady C29
  28. Callahan MA30
  29. Caorsi R31
  30. Carbone J32
  31. Carrabba M33
  32. Castagnoli R34, 35
  33. Catanzaro JR36
  34. Chan S37, 137
  35. Chandra S3, 4
  36. Chapdelaine H39
  37. Chavoshzadeh Z40
  38. Chong HJ41
  39. Connors L42
  40. Consonni F43
  41. Correajimenez O44
  42. Cunninghamrundles C2
  43. Dastousgauthier K45
  44. Delmonte OM24
  45. Demirdag YY46
  46. Deshpande DR47
  47. Diazcabrera NM48
  48. Dimitriades VR49
  49. Elowaidy R50
  50. Elghazali G51
  51. Alhammadi S52
  52. Fabio G33
  53. Faure AS53
  54. Feng J54
  55. Fernandez JM55
  56. Fill L57
  57. Franco GR58
  58. Frenck RW4, 59
  59. Fuleihan RL60
  60. Giardino G61
  61. Galantswafford J62
  62. Gambineri E43, 64
  63. Garabedian EK65
  64. Geerlinks AV66
  65. Goudouris E67
  66. Grecco O58
  67. Panhammarstrom Q5
  68. Khani HHK40
  69. Hammarstrom L5
  70. Hartog NL68
  71. Heimall J69
  72. Hernandezmolina G70
  73. Horner CC71
  74. Hostoffer RW57
  75. Hristova N72
  76. Hsiao KC73, 74, 75
  77. Ivankovichescoto G76
  78. Jaber F54
  79. Jalil M77
  80. Jamee M79
  81. Jean T46
  82. Jeong S54
  83. Jhaveri D80
  84. Jordan MB3, 4, 81
  85. Joshi AY82
  86. Kalkat A57
  87. Kanarek HJ83
  88. Kellner ES84
  89. Khojah A85
  90. Khoury R3, 4
  91. Kokron CM58
  92. Kumar A3, 4
  93. Lecerf K86
  94. Lehman HK87
  95. Leiding JW88
  96. Lesmana H89
  97. Lim XR90
  98. Lopes JP91
  99. Lopez AL92
  100. Tarquini L93
  101. Lundgren IS94
  102. Magnusson J95
  103. Marinho AKBB58
  104. Marseglia GL34
  105. Martone GM87
  106. Mechtler AG96
  107. Mendonca L58, 97
  108. Milner JD98
  109. Mustillo PJ99
  110. Naderi AG100
  111. Naviglio S102
  112. Nell J103
  113. Niebur HB104
  114. Notarangelo L24
  115. Oleastro M26
  116. Ortegalopez MC105
  117. Patel NR106
  118. Petrovic G107
  119. Pignata C108
  120. Porras O109
  121. Prince BT99
  122. Puck JM110
  123. Qamar N111
  124. Rabusin M102
  125. Raje N17
  126. Regairaz L113
  127. Risma KA114
  128. Ristagno EH115
  129. Routes J116
  130. Roxojunior P117
  131. Salemi N118
  132. Scalchunes C119
  133. Schuval SJ120
  134. Seneviratne SL121
  135. Shankar A57
  136. Sherkat R118
  137. Shin JJ122
  138. Siddiqi A123
  139. Signa S31
  140. Sobh A124
  141. Lima FMS58
  142. Stenehjem KK106
  143. Tam JS125
  144. Tang M126
  145. Barros MT58
  146. Verbsky J116
  147. Vergadi E127
  148. Voelker DH128
  149. Volpi S31, 129
  150. Wall LA130
  151. Wang C131
  152. Williams KW132
  153. Wu EY133
  154. Wu SS134, 135
  155. Zhou JJ37, 137
  156. Cook A116
  157. Sullivan KE15
  158. Marsh R3, 4

Source: Journal of Clinical Immunology Published:2024


Abstract

Background: The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, and whether vaccination attenuates infection severity in IEI. Objective: To estimate COVID-19 vaccination safety and examine effect on outcomes in patients with IEI. Methods: We built a secure registry database in conjunction with the US Immunodeficiency Network to examine vaccination frequency and indicators of safety and effectiveness in IEI patients. The registry opened on January 1, 2022, and closed on August 19, 2022. Results: Physicians entered data on 1245 patients from 24 countries. The most common diagnoses were antibody deficiencies (63.7%). At least one COVID-19 vaccine was administered to 806 patients (64.7%), and 216 patients received vaccination prior to the development of COVID-19. The most common vaccines administered were mRNA-based (84.0%). Seventeen patients were reported to seek outpatient clinic or emergency room care for a vaccine-related complication, and one patient was hospitalized for symptomatic anemia. Eight hundred twenty-three patients (66.1%) experienced COVID-19 infection. Of these, 156 patients required hospitalization (19.0%), 47 required ICU care (5.7%), and 28 died (3.4%). Rates of hospitalization (9.3% versus 24.4%, p < 0.001), ICU admission (2.8% versus 7.6%, p = 0.013), and death (2.3% versus 4.3%, p = 0.202) in patients who had COVID-19 were lower in patients who received vaccination prior to infection. In adjusted logistic regression analysis, not having at least one COVID-19 vaccine significantly increased the odds of hospitalization and ICU admission. Conclusion: Vaccination for COVID-19 in the IEI population appears safe and attenuates COVID-19 severity. © The Author(s) 2024.
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