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Covid-19 Vaccination in Patients With Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to Covid-19: A Usidnet Report Publisher Pubmed



Mcdonnell J1 ; Cousins K2 ; Younger MEM136 ; Lane A3, 4 ; Abolhassani H5, 6 ; Abraham RS7, 8 ; Altamemi S9 ; Aldavebecerra JC10 ; Alfaris EH11 ; Alfaromurillo A12 ; Alkhater SA13, 14 ; Alsaati N15 ; Doss AMA16 ; Anderson M17 Show All Authors
Authors
  1. Mcdonnell J1
  2. Cousins K2
  3. Younger MEM136
  4. Lane A3, 4
  5. Abolhassani H5, 6
  6. Abraham RS7, 8
  7. Altamemi S9
  8. Aldavebecerra JC10
  9. Alfaris EH11
  10. Alfaromurillo A12
  11. Alkhater SA13, 14
  12. Alsaati N15
  13. Doss AMA16
  14. Anderson M17
  15. Angarola E18
  16. Ariue B19
  17. Arnold DE20
  18. Assaad AH21
  19. Aytekin C22
  20. Bank M23
  21. Bergerson JRE24
  22. Bleesing J3, 4
  23. Boesing J25
  24. Bouso C26
  25. Brodszki N27
  26. Cabanillas D28
  27. Cady C29
  28. Callahan MA30
  29. Caorsi R31
  30. Carbone J32
  31. Carrabba M33
  32. Castagnoli R34, 35
  33. Catanzaro JR36
  34. Chan S37, 137
  35. Chandra S3, 4
  36. Chapdelaine H39
  37. Chavoshzadeh Z40
  38. Chong HJ41
  39. Connors L42
  40. Consonni F43
  41. Correajimenez O44
  42. Cunninghamrundles C2
  43. Dastousgauthier K45
  44. Delmonte OM24
  45. Demirdag YY46
  46. Deshpande DR47
  47. Diazcabrera NM48
  48. Dimitriades VR49
  49. Elowaidy R50
  50. Elghazali G51
  51. Alhammadi S52
  52. Fabio G33
  53. Faure AS53
  54. Feng J54
  55. Fernandez JM55
  56. Fill L57
  57. Franco GR58
  58. Frenck RW4, 59
  59. Fuleihan RL60
  60. Giardino G61
  61. Galantswafford J62
  62. Gambineri E43, 64
  63. Garabedian EK65
  64. Geerlinks AV66
  65. Goudouris E67
  66. Grecco O58
  67. Panhammarstrom Q5
  68. Khani HHK40
  69. Hammarstrom L5
  70. Hartog NL68
  71. Heimall J69
  72. Hernandezmolina G70
  73. Horner CC71
  74. Hostoffer RW57
  75. Hristova N72
  76. Hsiao KC73, 74, 75
  77. Ivankovichescoto G76
  78. Jaber F54
  79. Jalil M77
  80. Jamee M79
  81. Jean T46
  82. Jeong S54
  83. Jhaveri D80
  84. Jordan MB3, 4, 81
  85. Joshi AY82
  86. Kalkat A57
  87. Kanarek HJ83
  88. Kellner ES84
  89. Khojah A85
  90. Khoury R3, 4
  91. Kokron CM58
  92. Kumar A3, 4
  93. Lecerf K86
  94. Lehman HK87
  95. Leiding JW88
  96. Lesmana H89
  97. Lim XR90
  98. Lopes JP91
  99. Lopez AL92
  100. Tarquini L93
  101. Lundgren IS94
  102. Magnusson J95
  103. Marinho AKBB58
  104. Marseglia GL34
  105. Martone GM87
  106. Mechtler AG96
  107. Mendonca L58, 97
  108. Milner JD98
  109. Mustillo PJ99
  110. Naderi AG100
  111. Naviglio S102
  112. Nell J103
  113. Niebur HB104
  114. Notarangelo L24
  115. Oleastro M26
  116. Ortegalopez MC105
  117. Patel NR106
  118. Petrovic G107
  119. Pignata C108
  120. Porras O109
  121. Prince BT99
  122. Puck JM110
  123. Qamar N111
  124. Rabusin M102
  125. Raje N17
  126. Regairaz L113
  127. Risma KA114
  128. Ristagno EH115
  129. Routes J116
  130. Roxojunior P117
  131. Salemi N118
  132. Scalchunes C119
  133. Schuval SJ120
  134. Seneviratne SL121
  135. Shankar A57
  136. Sherkat R118
  137. Shin JJ122
  138. Siddiqi A123
  139. Signa S31
  140. Sobh A124
  141. Lima FMS58
  142. Stenehjem KK106
  143. Tam JS125
  144. Tang M126
  145. Barros MT58
  146. Verbsky J116
  147. Vergadi E127
  148. Voelker DH128
  149. Volpi S31, 129
  150. Wall LA130
  151. Wang C131
  152. Williams KW132
  153. Wu EY133
  154. Wu SS134, 135
  155. Zhou JJ37, 137
  156. Cook A116
  157. Sullivan KE15
  158. Marsh R3, 4
Show Affiliations
Authors Affiliations
  1. 1. Pediatric Allergy and Immunology, Cleveland Clinic Children’s Hospital, 9500 Euclid Ave/R3, Cleveland, 44195, OH, United States
  2. 2. Clinical Immunology, Departments of Medicine and Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, United States
  3. 3. Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States
  4. 4. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States
  5. 5. Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden
  6. 6. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Pathology and Laboratory Medicine, Nationwide Children’s Hospital, Columbus, United States
  8. 8. Dept of Pathology, The Ohio State Univ Wexner College of Medicine, Columbus, United States
  9. 9. Department of Child Health, Sultan Qaboos University Hospital, Muscat, Oman
  10. 10. Allergy and Clinical Immunology, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru
  11. 11. Department of Internal Medicine, King Fahad Specialist Hospital, Dammam, Saudi Arabia
  12. 12. Department of Internal Medicine and Clinical Immunology, Hospital San Juan de Dios, San Jose, Costa Rica
  13. 13. Department of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
  14. 14. King Fahd Hospital of University, Al-Khobar, Saudi Arabia
  15. 15. Division of Allergy and Immunology, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States
  16. 16. Division of Pediatric Allergy, Immunology, and Pulmonary Medicine, St. Louis Children’s Hospital, St. Louis, MO, United States
  17. 17. Division of Allergy Immunology Pulmonary and Sleep Medicine, Department of Pediatrics, Children’s Mercy Kansas City, University of Missouri-Kansas City, Kansas City, MO, United States
  18. 18. Immunology and Histocompatibility Unit, Hospital C. G. Durand, Buenos Aires, Argentina
  19. 19. Department of Pediatrics, Division of Allergy and Immunology, Loma Linda Children’s Hospital, Loma Linda, CA, United States
  20. 20. Immune Deficiency-Cellular Therapy Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States
  21. 21. Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States
  22. 22. Department of Pediatric Immunology, Dr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital, Ankara, Turkey
  23. 23. Department of Internal Medicine, Louisiana State University Health Sciences Center, New Orleans, United States
  24. 24. Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Rockville, MD, United States
  25. 25. Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States
  26. 26. Immunology Department, Hospital Nacional de Pediatria Prof. Dr. Juan P. Garrahan, Buenos Aires, Argentina
  27. 27. Department of Pediatric Immunology, Children’s Hospital, Lund University Hospital, Lund, Sweden
  28. 28. Immunology Unit-Hospital Sor Maria Ludovica, La Plata, Argentina
  29. 29. Community Medical Center, Missoula, MT, United States
  30. 30. Lake Erie College of Osteopathic Medicine, Elmira, United States
  31. 31. Center for Autoinflammatory Diseases and Immunodeficiencies, IRCCS Istituto Giannina Gaslini, Genoa, 16147, Italy
  32. 32. Immunology Department, Hospital General Universitario Gregorio Maranon, Madrid, Spain
  33. 33. Department of Medicine, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
  34. 34. Pediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy
  35. 35. Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  36. 36. Section of Pulmonology, Allergy, Immunology and Sleep Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT, United States
  37. 37. Department of Clinical Immunology & amp
  38. 38. Allergy, Royal Melbourne Hospital, Melbourne, VIC, Australia
  39. 39. Clinical Immunology, Montreal Clinical Research Institute, Universite de Montreal, Montreal, Canada
  40. 40. Immunology and Allergy Department, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  41. 41. Division of Allergy and Immunology, UPMC Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States
  42. 42. Department of Medicine, Dalhousie University, Halifax, NS, Canada
  43. 43. Centre of Excellence, Division of Pediatric Oncology and Hematology, Meyer Children’s Hospital IRCCS, Florence, Italy
  44. 44. Pediatric Pulmonology and Immunology Research Group, Universidad Nacional de Colombia, Bogota, Colombia
  45. 45. Department of Pediatric Clinical Immunology and Allergy, University of Sherbrooke, Sherbrooke, QC, Canada
  46. 46. Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, CA, United States
  47. 47. Department of Pediatrics, Columbia University Medical Center, New York, NY, United States
  48. 48. Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, FL, United States
  49. 49. Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of California Davis Health, Sacramento, CA, United States
  50. 50. Pediatric Allergy, Immunology and Rheumatology Unit, Children’s Hospital, Ain Shams University, Cairo, Egypt
  51. 51. Abu Dhabi and College of Medicine and Health Sciences, Sheikh Khalifa Medical City, Union71 - Purehealth, United Arab Emirates University, Al Ain, United Arab Emirates
  52. 52. College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates
  53. 53. Hospital Sor Maria Ludovica, La Plata, Argentina
  54. 54. Clinical Immunology, Department of Medicine at Icahn School of Medicine at Mount Sinai, New York, NY, United States
  55. 55. Department of Allergy & amp
  56. 56. Clinical Immunology, Cleveland Clinic Foundation, Cleveland, OH, United States
  57. 57. University Hospitals, Cleveland Medical Centers, Cleveland, OH, United States
  58. 58. Division of Clinical Immunology and Allergy, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
  59. 59. Division of Infectious Disease, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States
  60. 60. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University Medical Center, New York, NY, United States
  61. 61. Pediatric Section, Department of Translational Medical Science, Federico II University, Naples, Italy
  62. 62. Division of Allergy & amp
  63. 63. Clinical Immunology, National Jewish Health, Denver, CO, United States
  64. 64. Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy
  65. 65. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, United States
  66. 66. Pediatric Hematology and Oncology, Children’s Hospital, Western University, London, ON, Canada
  67. 67. Division of Allergy and Clinical Immunology – IPPMG, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, Brazil
  68. 68. Helen DeVos Children’s Hospital Division of Allergy and Immunology, Michigan State University College of Human Medicine, East Lansing, MI, United States
  69. 69. Division of Allergy and Immunology, Department of Pediatrics, Perelman School of Medicine at University of Pennsylvania, Children’s Hospital of Philadelphia, Philadelphia, 19104, PA, United States
  70. 70. Immunology and Rheumatology Department, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
  71. 71. Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, United States
  72. 72. Department of Clinical Immunology and Stem Cell Bank, University Hospital Alexandrovska, Sofia, Bulgaria
  73. 73. Starship Child Health, Auckland, New Zealand
  74. 74. Department of Paediatrics: Child and Youth Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
  75. 75. Clinical Immunogenomics Research Consortium Australasia, Sydney, Australia
  76. 76. Department of Pediatrics, Caja Costarricense de Seguro Social, Hospital Nacional de Ninos, San Jose, Costa Rica
  77. 77. Advanced ENT & amp
  78. 78. Allergy, Medford, NJ, United States
  79. 79. Pediatric Nephrology Research Center, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  80. 80. Allergy Immunology Associates Inc., Allergy Immunology Fellowship Associate Program Director University Hospitals of Cleveland Medical Center, Cleveland, United States
  81. 81. Division of Immunobiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States
  82. 82. Mayo Clinic Children’s Center, Pediatric and Adult Allergy and Immunology, Mayo Clinic, Rochester, MN, United States
  83. 83. Kanarek Allergy Asthma Immunology, Overland Park, KS, United States
  84. 84. Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center and University of Cincinnati, Cincinnati, OH, United States
  85. 85. Department of Pediatrics, College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia
  86. 86. Division of Allergy and Immunology, Department of Pediatrics, Nationwide Children’s Hospital and The Ohio State University College of Medicine, Columbus, OH, United States
  87. 87. Department of Pediatrics, University of Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, United States
  88. 88. Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, MD, United States
  89. 89. Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, United States
  90. 90. Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore
  91. 91. UH Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, OH, United States
  92. 92. Unidad de Inmunologia E Histocompatibilidad, Hospital Dr. Carlos G. Durand, Buenos Aires, Argentina
  93. 93. Section of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region, Ancona, 60020, Italy
  94. 94. Pediatric Infectious Diseases, St. Luke’s Children’s Hospital, Boise, ID, United States
  95. 95. USIDNET, Towson, MD, United States
  96. 96. University of Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, United States
  97. 97. Center for Rare and Immunological Diseases, Hospital 9 de Julho - Rede DASA, Sao Paulo, Brazil
  98. 98. Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, United States
  99. 99. Division of Allergy and Immunology, Department of Pediatrics, Nationwide Children’s Hospital and The Ohio State University Wexner College of Medicine, Columbus, OH, United States
  100. 100. Allergy & amp
  101. 101. Immunology, Keck School of Medicine of USC, Los Angeles, CA, United States
  102. 102. Pediatric Hematology-Oncology, Institute for Maternal and Child Health IRCCS “Burlo Garofolo, ”, Trieste, Italy
  103. 103. Department of Infection and Tropical Medicine, Newcastle Upon Tyne Hospitals National Health Service (NHS) Foundation Trust and Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom
  104. 104. Department of Pediatrics, University of Nebraska Medical Center, Children’s Hospital and Medical Center, Omaha, NE, United States
  105. 105. Division of Pediatrics, Allergy and Clinical Immunology, Hospital Infantil Universitario de San Jose, Bogota, Colombia
  106. 106. Department of Pediatrics, Children’s National Hospital, Washington, DC, United States
  107. 107. Department of Clinical Immunology and Allergology, Institute of Mother and Child Health, Belgrade, Serbia
  108. 108. Pediatrics, Department of Translational Medical Sciences, Federico II University, Naples, Italy
  109. 109. Pediatric Immunology and Rheumatology Department, Hospital Nacional de Ninos “Dr. Carlos Saenz Herrera, ”, San Jose, Costa Rica
  110. 110. Division of Allergy and Immunology and Blood and Marrow Transplantation, Department of Pediatrics, University of California San Francisco School of Medicine and UCSF Benioff Children’s Hospital, San Francisco, CA, United States
  111. 111. Division of Allergy and Immunology, Department of Pediatrics, Ann & amp
  112. 112. Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
  113. 113. Chief of Immunology Unit, Children’s Hospital “Sor Maria Ludovica, Buenos Aires, Argentina
  114. 114. Division of Allergy Immunology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States
  115. 115. Division of Pediatric Infectious Diseases, Mayo Clinic, Rochester, MN, United States
  116. 116. Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States
  117. 117. Division of Immunology and Allergy, Department of Pediatrics, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil
  118. 118. Immunodeficiency Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  119. 119. Immune Deficiency Foundation, 7550 Teague Road, Hanover, 21076, MD, United States
  120. 120. Division of Allergy and Immunology, Stony Brook Children’s Hospital, Stony Brook, NY, United States
  121. 121. Department of Clinical Immunology, Nawaloka Hospitals, Colombo, Sri Lanka
  122. 122. Section of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, United States
  123. 123. Houston ENT and Allergy, Houston, TX, United States
  124. 124. Department of Pediatrics, Faculty of Medicine, Mansoura University Children’s Hospital, Mansoura University, Mansoura, Egypt
  125. 125. Children’s Hospital Los Angeles, Los Angeles, CA, United States
  126. 126. Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California San Francisco, San Francisco, United States
  127. 127. Department of Paediatrics, Medical School, University of Crete, Rethymno, Greece
  128. 128. Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States
  129. 129. Dipartimento Di NeuroscienzeRiabilitazioneOftalmologiaGenetica e Scienze Materno Infantili, University of Genoa, Genoa, 16132, Italy
  130. 130. Section of Allergy Immunology, Department of Pediatrics, Louisiana State University Health and Children’s Hospital New Orleans, New Orleans, LA, United States
  131. 131. Section of Rheumatology, Department of Pediatrics, Children’s Hospital of Colorado, University of Colorado School of Medicine, Aurora, CO, United States
  132. 132. Division of Pediatric Pulmonology, Allergy and Immunology, Department of Pediatrics, Medical University of South Carolina, Charleston, SC, United States
  133. 133. Division of Pediatric Allergy and Immunology, Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
  134. 134. University Hospitals Cleveland Medical Center, Cleveland, OH, United States
  135. 135. Allergy and Immunology Associates Inc., Mayfield Heights, OH, United States
  136. 136. Johns Hopkins University School of Medicine, Baltimore, MD, United States
  137. 137. Department of Clinical Immunology & amp
  138. 138. Allergy, The Royal Melbourne Hospital, Melbourne, Australia

Source: Journal of Clinical Immunology Published:2024


Abstract

Background: The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, and whether vaccination attenuates infection severity in IEI. Objective: To estimate COVID-19 vaccination safety and examine effect on outcomes in patients with IEI. Methods: We built a secure registry database in conjunction with the US Immunodeficiency Network to examine vaccination frequency and indicators of safety and effectiveness in IEI patients. The registry opened on January 1, 2022, and closed on August 19, 2022. Results: Physicians entered data on 1245 patients from 24 countries. The most common diagnoses were antibody deficiencies (63.7%). At least one COVID-19 vaccine was administered to 806 patients (64.7%), and 216 patients received vaccination prior to the development of COVID-19. The most common vaccines administered were mRNA-based (84.0%). Seventeen patients were reported to seek outpatient clinic or emergency room care for a vaccine-related complication, and one patient was hospitalized for symptomatic anemia. Eight hundred twenty-three patients (66.1%) experienced COVID-19 infection. Of these, 156 patients required hospitalization (19.0%), 47 required ICU care (5.7%), and 28 died (3.4%). Rates of hospitalization (9.3% versus 24.4%, p < 0.001), ICU admission (2.8% versus 7.6%, p = 0.013), and death (2.3% versus 4.3%, p = 0.202) in patients who had COVID-19 were lower in patients who received vaccination prior to infection. In adjusted logistic regression analysis, not having at least one COVID-19 vaccine significantly increased the odds of hospitalization and ICU admission. Conclusion: Vaccination for COVID-19 in the IEI population appears safe and attenuates COVID-19 severity. © The Author(s) 2024.
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