Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Association of the Length of Ca Dinucleotide Repeat in the Epidermal Growth Factor Receptor With Risk and Age of Breast Cancer Onset in Isfahan



Jami MS1 ; Tavassolia M1 ; Hemati S1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Faculty of Science, University of Isfahan, Iran
  2. 2. School of Medicine, Isfahan University of Medical Sciences

Source: Journal of Isfahan Medical School Published:2008

Abstract

Background: The epidermal growth factor receptor (EGFR) also known as HER1 or ErbB1 is a prominent member of the erbB proto-oncogene family, which encodes a receptor tyrosine kinase with a pivotal role in the regulation of cell growth and differentiation. The aim of this research was to study the CA repeat polymorphism in intron I of EGFR among the patients with breast cancer and healthy controls. We have also evaluated risks for breast cancer, age of onset and grade of tumor associated with the CA repeat polymorphism. Methods: In the present work, the association of breast cancer with the polymorphic CA repeat in 108 cases of breast cancer and 108 matched controls was studied. After DNA extraction from blood, CA dinucleotide region was amplified by PCR technique and the number of CA repeats was determined by polyacrylamide gel electrophoresis and sequencing. Findings: Our findings demonstrate that women with two short CA repeat (<19) are at a significantly higher risk of breast cancer, at an estimated odds ratio of 1.86. We have also found that women with short alleles (<19) had much greater risk of developing cancer before the age of 55 (OR=3.36). Conclusion: Our results suggested that shorter CA repeat length may be associated not only with the risk of breast cancer but also with the age of developing cancer in Isfahanian population. We did not find any relation between the CA repeats length and tumor staging. © 2008, Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. The Association Between Ca Polymorphism in Src Gene and Risk of Breast Cancer, Journal of Isfahan Medical School (2017)
2. The Study of Taaaa Polymorphism in P53 Gene and Its Association With Breast Cancer, Journal of Isfahan Medical School (2015)
3. The Relationship of Cac Polymorphism in Hoxa1 Gene and Breast Cancer, Journal of Isfahan Medical School (2014)
4. Association Between the Lengths of Gt Dinucleotide Repeat in the Pik3ca Gene With Breast Cancer Risk, Medical Oncology (2014)
5. Ggcn Polymorphism of Erf3a/Gspt1 Gene and Breast Cancer Susceptibility, Medical Oncology (2012)
6. Trinucleotide Repeat Polymorphism in Transforming Growth Factor Beta Receptor Type 1 Gene and Risk of Breast Cancer, Journal of Isfahan Medical School (2013)
7. Polymorphic Aaag Repeat Length in Estrogen-Related Receptor Gamma (Errγ) and Risk of Breast Cancer in Iranian Women, Cancer Investigation (2013)
8. Polymorphic Gt Dinucleotide Repeat in the Pik3ca Gene and Its Association With Colorectal Cancer Risk, Journal of Isfahan Medical School (2015)
Experts (# of related papers)
View all Related Experts
Simin Hemati (16)
Azar Baradaran (3)
Other Related Docs
9. Tp53 Pin3 Polymorphism Associated With Breast Cancer Risk in Iranian Women, Indian Journal of Cancer (2011)
10. Polymorphisms of Satellite Dna Cyp19 Gene and Its Association With Increased Risk of Breast Cancer in Isfahan, Iran, Journal of Isfahan Medical School (2012)
11. Tgfbr1 Polymorphism and Risk of Breast Cancer in Iranian Women, International Journal of Biological Markers (2015)
12. Association of P53 (+16Ins-Arg) Haplotype With the Increased Susceptibility to Breast Cancer in Iranian-Azeri Women, Journal of Kerman University of Medical Sciences (2018)
13. Eukaryotic Release Factor 3 and Risk of Breast Cancer, Journal of Isfahan Medical School (2013)
14. Association Between the Length of a Ca Dinucleotide Repeat in the C-Src Gene and Risk of Prostate Cancer, Journal of Isfahan Medical School (2018)
15. Igf1 Ca-Repeat Polymorphism and Prostate Cancer Development in Isfahan Province of Iran, Journal of Kerman University of Medical Sciences (2018)
16. Association of Pon1-L55m Genetic Variation and Breast Cancer Risk: A Case-Control Trial, Asian Pacific Journal of Cancer Prevention (2020)
17. The Prevalence of Ataxia Telangiectasia Mutated (Atm) Variants in Patients With Breast Cancer Patients: A Systematic Review and Meta-Analysis, Cancer Cell International (2021)
18. Study of P53 Polymorphism at Codon 72 in Patients of Breast Cancer in Isfahan, Journal of Isfahan Medical School (2007)
19. Lack of Association Between Esr1 and Cyp1a1 Gene Polymorphisms and Susceptibility to Uterine Leiomyoma in Female Patients of Iranian Descent, Cell Journal (2014)
20. Evaluation of Relative Frequency of Single Nucleotide Polymorphism G870a (Rs9344) in Cyclind1 Gene in Colorectal Cancer Patients and Healthy Subjects of Isfahan Province, Iran, Journal of Isfahan Medical School (2016)
21. Screening Brca1 and Brca2 Mutation Frequencies in Breast Cancer Patients of West Iran Reveals a Novel Polymorphism in Brca1 Gene; [«L’Indagine Sulla Frequenza Di Mutazione Dei Brca1 E Brca2 in Pazienti Con Tumore Mammario Dell’Iran Occidentale Evidenzia Un Nuovo Polimorfismo Del Gene Brca1»], European Journal of Oncology (2015)
22. The Direct Medical Costs of Breast Cancer in Iran: Analyzing the Patient's Level Data From a Cancer Specific Hospital in Isfahan, International Journal of Preventive Medicine (2013)
23. The Association Between Cyclin D1 (Ccnd1) Rs9344 Aa Genotype and Increased Risk of Colorectal Cancer in an Iranian Population, Middle East Journal of Cancer (2020)
24. Fto Genotype Was Associated With Breast Cancer in Her2 Negative Patients, Clinical Nutrition ESPEN (2022)
25. Association of Apai and Taqi Polymorphisms in Vdr Gene With Breast Cancer, Asian Pacific Journal of Cancer Prevention (2020)
26. A Comparison Between Full-Cold Pcr/Hrm and Pcr Sequencing for Detection of Mutations in Exon 9 of Pik3ca in Breast Cancer Patients, Applied Biochemistry and Biotechnology (2019)
27. Frequent Esr1 and Cdk Pathway Copy-Number Alterations in Metastatic Breast Cancer, Molecular Cancer Research (2019)
28. Genomic Rearrangement Screening of the Brca1 From Seventy Iranian High-Risk Breast Cancer Families, Journal of Research in Medical Sciences (2016)
29. Association of Programmed Death-1 Gene Polymorphisms With the Risk of Basal Cell Carcinoma, International Journal of Immunogenetics (2019)
30. Risk Factors of Developing a Second Malignancy Following Treatment of a First Primary Breast Cancer, Iranian Journal of Cancer Prevention (2013)
31. Comparison of Dna Instability in Adenoma and Adenocarcinoma in Patients With Colorectal Cancer, Using Random Amplified Polymorphic Dna Polymerase Chain Reaction (Rapd-Pcr), Journal of Isfahan Medical School (2017)
32. Multicentricity in Different Molecular Subtypes of Breast Cancer: A Cross-Sectional Study in Isfahan, Advanced Biomedical Research (2023)
33. Evaluation of the Relative Frequency of Epstein-Barr Virus Infection in Patients With Recurrent Breast Cancer Compared With Patients With Nonrecurrent Breast Cancer, Advanced Biomedical Research (2023)
34. St6gal1, Cox-2 and Hb-Egf Mrna Expression in Breast Cancer Samples From Kashan, Iran, Middle East Journal of Cancer (2015)
35. Investigation of Prognostic Factors in Breast Cancer and Their Relationship With Age and Cancer Stage, Journal of Isfahan Medical School (2012)
36. Investigating of Variations in Brca1 Gene in Iranian Families With Breast Cancer, Medical Journal of the Islamic Republic of Iran (2018)
37. A Study of the Long-Term Trend of Epidemiological and Clinical Indices of Breast Cancer in Isfahan, Journal of Isfahan Medical School (2012)
38. Evaluation of Immunohistochemistry Technique in Detecting Her2 Overexpression in Invasive Ductal Breast Carcinoma Using Fluorescence In-Situ Hybridization Method, Journal of Isfahan Medical School (2016)
39. Programmed Cell Death 1 (Pdcd1) Gene Haplotypes and Susceptibility of Patients to Basal Cell Carcinoma, Molecular Biology Reports (2021)
40. Lack of Significance of the Brca2 Promoter Methylation Status in Different Genotypes of the Mthfr A1298c Polymorphism in Ovarian Cancer Cases in Iran, Asian Pacific Journal of Cancer Prevention (2012)
41. Involvement of Single Nucleotide Polymorphisms in Acute Lymphoblastic Leukemia Susceptibility, Gene Reports (2020)
42. Investigating the Prevalence of Brca1 and Brca2 Gene Mutations in Patients With Breast Cancer, Journal of Isfahan Medical School (2013)
43. Validity of Immunohistochemistry Method in Predicting Her-2 Gene Status and Association of Clinicopathological Variables With It in Invasive Breast Cancer Patients, APMIS (2016)
44. The Study of Taaaa Repeat Polymorphism in P53 Gene and Its Association With Prostate Cancer, Journal of Isfahan Medical School (2016)