Comparative Efficacy of Probiotic Yoghurt and Clindamycin in Treatment of Bacterial Vaginosis in Pregnant Women: A Randomized Clinical Trial Publisher Pubmed



Hantoushzadeh S¹ ; Golshahi F² ; Javadian P^{1, 2} ; Khazardoost S³ ; Aram S⁴ ; Hashemi S³ ; Mirarmandehi B³ ; Borna S¹
Source: Journal of Maternal-Fetal and Neonatal Medicine Published:2012

Abstract

Objective: This study was performed to determine the comparative efficacy of probiotic yoghurt and clindamycin in the treatment of bacterial vaginosis in pregnant women in the third trimester. Methods and materials: This randomized clinical trial was performed as an open-label study. 310 symptomatic patients with BV were recruited. Diagnosis of BV was through Amsel criteria. The patients were randomly assigned to receive either probiotic yoghurt (100g twice a day/week) or orally administered clindamycin (300mg twice a day/week). Results: Ten patients in probiotic group and 9 subjects in clindamycin group had symptom recurrence (p>0.05). 132 patients in probiotic group and 105 subjects in clindamycin group had pH decrease (p<0.0001). 140 patients in probiotic group and 141 subjects in clindamycin group had complete symptomatic cure (p>0.05). Twelve patients in probiotic group and seven subjects in clindamycin group had preterm birth. Nine women in probiotic group and five subjects in clindamycin group had PROM (p>0.05). Conclusions: According to the obtained results, it may be concluded that probiotics would have a good efficacy in the treatment of bacterial vaginosis in pregnancy leading to decreased burden of subsequent preterm birth. © 2012 Informa UK, Ltd.