Antihyperglycemic and Antioxidant Activity of Crocin in Streptozotocin-Induced Diabetic Rats Publisher Pubmed



Rajaei Z^{1, 2, 3} ; Hadjzadeh MAR^{1, 2} ; Nemati H^{1, 2} ; Hosseini M^{1, 2} ; Ahmadi M² ; Shafiee S² Show Affiliations
Source: Journal of Medicinal Food Published:2013

Abstract

The aim of the present study was to investigate the antihyperglycemic and protective potential of crocin, a pharmacologically active constituent of Crocus sativus L., in streptozotocin-induced diabetic rats. Rats were administered crocin intraperitoneally at doses of 15, 30, and 60 mg/kg of body weight for 6 weeks. The levels of thiobarbituric acid reactive substance (TBARS) and total thiol (SH) groups were measured in the liver and kidney at the end of 6 weeks. Under our experimental conditions, crocin at a dose of 60 mg/kg was found to significantly reduce the blood glucose level in diabetic animals. In addition, there was a significant increase in TBARS levels and decreased total thiol concentrations in the liver and kidney of diabetic animals. Crocin, at doses of 30 and 60 mg/kg, appears to exert an antioxidative activity demonstrated by a lowering of lipid peroxidation levels in these organs. In conclusion, our findings suggest that crocin has the hypoglycemic and antioxidative properties in streptozotocin-induced diabetes and it may be useful in the management of diabetic patients. © Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition.