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Effects of Bread With Nigella Sativa on Hematologic Factors in Metabolic Syndrome Patients Publisher



Mohtashami A1 ; Mahaki B2 ; Azadbakht L3 ; Entezari MH4
Authors
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Authors Affiliations
  1. 1. Faculty of Medical Sciences, Islamic Azad University of Chalus, Chalus, Iran
  2. 2. Department of Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Tehran University of Medical Sciences, Department of Community Nutrition, School of Nutritional Science and Dietetics, Tehran, Iran
  4. 4. Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Progress in Nutrition Published:2018


Abstract

Background: Nigella sativa (N. sativa) has been used in traditional medicine and many studies have been performed in different communities in order to reveal the effects of it on medical disorders and chronic diseases. Purpose: The aim of this study was the investigation of effects of bread with N. sativa on hematologic factors in metabolic syndrome (MetS) patients. Material and methods: A randomized, double-blind, cross-over, clinical trial was conducted in 51 MetS patients of both sexes with age group of 20-65 years old in Chalus, north of Iran. Patients randomly divided in two groups. In phase 1, Intervention group (A, n =27) received daily a regular bread with N. sativa and wheat bran and control group (B, n=24) received the same bread without N. sativa for 2 month. After 2 weeks wash out period, phase 2 was started with replacement of two groups. Measuring of red blood cells (RBC), white blood cells (WBC), prothrombin time(Pt), hematocrite (Hct) and hemoglobin (Hb) was performed for patients in before and after of two phases. Results: In this study evaluated treatment, sequence and time effects of crossover intervention and revealed that consumption of bread with N. sativa has not significant treatment and sequence effects on RBC, WBC, PT, Hct and Hb (p>0.05). Time effect was only significant on RBC (P<0.05) and was not on other factors (p>0.05). Conclusion: Consumption of bread with N. sativa has not significant effect on hematologic factors in MetS patients. © Mattioli 1885.
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