Nutritional Interventions in Amyotrophic Lateral Sclerosis: From Ketogenic Diet and Neuroprotective Nutrients to the Microbiota-Gut-Brain Axis Regulation Publisher Pubmed



S Nabakhteh SAMIRA ; A Lotfi ANAHITA ; A Afsartaha ARMAN ; Es Khodadadi Elaheh SADAT ; S Abdolghaderi SIAVASH ; M Mohammadpour MOZHDEH ; Y Shokri YASAMAN ; P Kiani POURIA ; S Ehtiati SAJAD ; S Khakshournia SARA
Source: Molecular Neurobiology Published:2025

Abstract

Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease with significant challenges in diagnosis and treatment. Recent research has highlighted the complex nature of ALS, encompassing behavioral impairments in addition to its neurological manifestations. While several medications have been approved to slow disease progression, ongoing research is focused on identifying new therapeutic targets. The current review focuses on emerging therapeutic strategies and personalized approaches aimed at improving patient outcomes. Recent advancements highlight the importance of targeting additional pathways such as mitochondrial dysfunction and neuroinflammation to develop more effective treatments. Personalized medicine, including genetic testing and biomarkers, is proving valuable in stratifying patients and tailoring treatment options. Complementary therapies, such as nutritional interventions like the ketogenic diet and microbiome modulation, also show promise. This review emphasizes the need for a multidisciplinary approach that integrates early diagnosis, targeted treatments, and supportive care to address the multisystemic nature of ALS and improve the quality of life for patients. © 2025 Elsevier B.V., All rights reserved.