Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effect of Process Parameters on the Size and Morphology of Poly(D, L-Lactide-Co-Glycolide) Micro/Nanoparticles Prepared by an Oil in Oil Emulsion/Solvent Evaporation Technique Publisher



Mahdavi H1 ; Mirzadeh H1 ; Hamishehkar H2 ; Jamshidi A1 ; Fakhari A1 ; Emami J3 ; Najafabadi AR4 ; Gilani K4 ; Minaiyan M3 ; Najafi M1 ; Tajarod M1 ; Nokhodchi A5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Novel Drug Delivery Systems and Biomaterial Department, Science Faculty, Iran Polymer and Petrochemical Institute, Tehran, Iran
  2. 2. Department of Pharmaceutical Technology, Drug Applied Research Center, Tabriz University (Medical Sciences), Tabriz, Iran
  3. 3. School of Pharmacy and Pharmaceutical Sciences, Isfahan Pharmaceutical Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Aerosol Research Laboratory, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Medway School of Pharmacy, Universities of Kent and Greenwich, Kent ME4 4TB, Chatham Maritime, United Kingdom

Source: Journal of Applied Polymer Science Published:2010


Abstract

For the past few decades, there has been a considerable research interest in the area of biodegradable polymeric micro- and nanoparticles for tissue engineering, regenerative medicine, implants, stents, medical devices, and drug delivery systems. Poly(D, L-lactide-coglycolide) (PLGA) is well-known by its safety in biomedical preparations which has been approved for human use by the FDA. The goal of this study was to evaluate the influence of process parameters on size characteristics of PLGA microparticles prepared by oil in oil (o/o) solvent evaporation technique. This method has been introduced as one of the most appropriate methods for hydrophilic agents. Scanning electron microscopy showed that prepared particles were spherical with smooth surface without aggregation. Particle size varied from 570 nm to 29 μm in different experimental conditions. Stirring speed, polymer concentration, impeller type, and dropping size had a significant effect on the particle size. The polydispersity index of particles showed a strong relationship with the surfactant concentration, impeller type, and dropping size. It was concluded that increasing in temperature up to 50°C or changing in dropping rate has a little effect on reducing the size of PLGA particles. The residual solvent content in the final suspension was less than 0.1 ppm that is in appropriate range for biomedical application. © 2009 Wiley Periodicals, Inc.
Related Docs
View other Related Docs
1. The Effect of Formulation Variables on the Characteristics of Insulin-Loaded Poly(Lactic-Co-Glycolic Acid) Microspheres Prepared by a Single Phase Oil in Oil Solvent Evaporation Method, Colloids and Surfaces B: Biointerfaces (2009)
2. Pulmonary Delivery of Docetaxel and Celecoxib by Plga Porous Microparticles for Their Synergistic Effects Against Lung Cancer, Anti-Cancer Agents in Medicinal Chemistry (2022)
3. Edible Wax-Based Nanoparticles As Novel Stabilizers for Oil-In-Water Pickering Emulsion, Food and Bioprocess Technology (2023)
4. Particle Size Design of Plga Microspheres for Potential Pulmonary Drug Delivery Using Response Surface Methodology, Journal of Microencapsulation (2009)
5. Formulation and Optimization of Celecoxib-Loaded Plga Nanoparticles by the Taguchi Design and Their in Vitro Cytotoxicity for Lung Cancer Therapy, Pharmaceutical Development and Technology (2015)
6. Enhancement of Oral Bioavailability of Pentoxifylline by Solid Lipid Nanoparticles, Journal of Liposome Research (2010)
7. Montelukast Incorporated Poly(Methyl Vinyl Ether-Co-Maleic Acid)/Poly(Lactic-Co-Glycolic Acid) Electrospun Nanofibers for Wound Dressing, Fibers and Polymers (2017)
8. Optimization of Freeze-Drying Condition of Amikacin Solid Lipid Nanoparticles Using D-Optimal Experimental Design, Pharmaceutical Development and Technology (2012)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (43)
Jaber Emami Baferani (14)
Other Related Docs
9. Nanostructured Lipid Carriers (Nlc): A Potential Delivery System for Bioactive Food Molecules, Innovative Food Science and Emerging Technologies (2013)
10. Synthesis, in Vitro Characterization, and Anti-Tumor Effects of Novel Polystyrene-Poly(Amide-Ether-Ester-Imide) Co-Polymeric Micelles for Delivery of Docetaxel in Breast Cancer in Balb/C Mice, Drug Development and Industrial Pharmacy (2018)
11. Fabrication of Edible Solid Lipid Nanoparticle From Beeswax/Propolis Wax by Spontaneous Emulsification: Optimization, Characterization and Stability, Food Chemistry (2022)
12. Fabrication of Polymeric Nanoparticles of Poly(Ethylene-Co-Vinyl Acetate) Coated With Chitosan for Pulmonary Delivery of Carvedilol, Journal of Applied Polymer Science (2014)
13. Fabrication and Characterization of a Novel Wound Dressing With Clindamycin Loaded Pva Nanoparticles for Acne Treatment, Fibers and Polymers (2022)
14. A Novel Approach to Prepare Insulin-Loaded Poly (Lactic-Co-Glycolic Acid) Microcapsules and the Protein Stability Study, Journal of Pharmaceutical Sciences (2009)
15. Bio-Nanocomposites As Food Packaging Materials; the Main Production Techniques and Analytical Parameters, Advances in Colloid and Interface Science (2022)
16. Freeze-Drying of Nanostructure Lipid Carriers by Different Carbohydrate Polymers Used As Cryoprotectants, Carbohydrate Polymers (2012)
17. Optimization of Self-Assembling Properties of Fatty Acids Grafted to Methoxy Poly(Ethylene Glycol) As Nanocarriers for Etoposide, Acta Pharmaceutica (2012)
18. Preparation and Characterization of Spray-Dried Inhalable Powders Containing Polymeric Micelles for Pulmonary Delivery of Paclitaxel in Lung Cancer, Journal of Pharmacy and Pharmaceutical Sciences (2018)
19. Influence of Carrier Particle Size, Carrier Ratio and Addition of Fine Ternary Particles on the Dry Powder Inhalation Performance of Insulin-Loaded Plga Microcapsules, Powder Technology (2010)
20. Preparation, Characterization and Optimization of Glipizide Controlled Release Nanoparticles, Research in Pharmaceutical Sciences (2014)
21. Releasing and Structural/Mechanical Properties of Nano-Particle//Punica Granatum (Pomegranate) in Poly(Lactic-Co-Glycolic) Acid/Fibrin As Nano-Composite Scaffold, Bratislava Medical Journal (2021)
22. Investigation of Lipidic Solid Nanoparticles From Propolis and Bees Waxes Produced by Antisolvent Precipitation Method, Journal of Food Science and Technology (Iran) (2021)
23. Preparation, Physicochemical, and Retinal Anti-Angiogenic Evaluation of Poloxamer Hydrogel Containing Dexamethasone/Avastin-Loaded Chitosan-N-Acetyl-L-Cysteine Nanoparticles, International Journal of Biological Macromolecules (2022)
24. Formulation of Ldl Targeted Nanostructured Lipid Carriers Loaded With Paclitaxel: A Detailed Study of Preparation, Freeze Drying Condition, and in Vitro Cytotoxicity, Journal of Nanomaterials (2012)
25. Preparation and Characterization of Celecoxib Dispersions in Soluplus®: Comparison of Spray Drying and Conventional Methods, Iranian Journal of Pharmaceutical Research (2015)
26. Screening the Most Effective Variables on Physical Properties of Folate-Targeted Dextran/Retinoic Acid Micelles by Taguchi Design, Journal of Nanomaterials (2012)
27. Production of Doxorubicin-Loaded Pcl Nanoparticles Through a Flow-Focusing Microfluidic Device: Encapsulation Efficacy and Drug Release, Soft Matter (2021)
28. Preparation and Characterization of an Injectable Thermosensitive Hydrogel for Simultaneous Delivery of Paclitaxel and Doxorubicin, Research in Pharmaceutical Sciences (2018)
29. Formulation and Characterization of Novel Nanostructured Lipid Carriers Made From Beeswax, Propolis Wax and Pomegranate Seed Oil, Food Chemistry (2018)
30. Thermosensitive Hydrogel Containing Sertaconazole Loaded Nanostructured Lipid Carriers for Potential Treatment of Fungal Keratitis, Pharmaceutical Development and Technology (2019)
31. Acceleration of Wound Healing in Rats by Modified Lignocellulose Based Sponge Containing Pentoxifylline Loaded Lecithin/Chitosan Nanoparticles, Gels (2022)
32. Double-Walled Microspheres Loaded With Meglumine Antimoniate: Preparation, Characterization and in Vitro Release Study, Drug Development and Industrial Pharmacy (2014)
33. Lycopene Nanodelivery Systems; Recent Advances, Trends in Food Science and Technology (2022)
34. Propolis Wax Nanostructured Lipid Carrier for Delivery of Β Sitosterol: Effect of Formulation Variables on Physicochemical Properties, Food Chemistry (2018)
35. Comparing Various Techniques to Produce Micro/Nanoparticles for Enhancing the Dissolution of Celecoxib Containing Pvp, European Journal of Pharmaceutics and Biopharmaceutics (2014)
36. Targeted Nanostructured Lipid Carriers for Delivery of Paclitaxel to Cancer Cells: Preparation, Characterization, and Cell Toxicity, Current Drug Delivery (2017)
37. Fabrication of Poly Hydroxybutyrate-Polyethylene Glycol-Folic Acid Nanoparticles Loaded by Paclitaxel, Current Drug Delivery (2016)
38. Development of Lecithin Nanoemulsion Based Organogels for Permeation Enhancement of Metoprolol Through Rat Skin, Journal of Nanomaterials (2013)
39. Pomegranate Seed Oil Nanoemulsion Enriched by Α-Tocopherol; the Effect of Environmental Stresses and Long-Term Storage on Its Physicochemical Properties and Oxidation Stability, Food Chemistry (2021)
40. Preparation and Characterization of a Hydroxypropyl Methylcellulose Based Wafer for Simultaneous Delivery of Phenytoin and Insulin As Wound Dressing Material, Pharmaceutical Development and Technology (2022)
41. Formulation and Optimization of Solid Lipid Nanoparticle Formulation for Pulmonary Delivery of Budesonide Using Taguchi and Box-Behnken Design, Research in Pharmaceutical Sciences (2015)
42. Transferrin-Targeted Poly(Butylene Adipate)/Terephthalate Nanoparticles for Targeted Delivery of 5-Fluorouracil in Ht29 Colorectal Cancer Cell Line, Journal of Bioactive and Compatible Polymers (2017)
43. An Injectable Carboxymethyl Chitosan-Methylcellulose-Pluronic Hydrogel for the Encapsulation of Meloxicam Loaded Nanoparticles, International Journal of Biological Macromolecules (2020)
44. Multiple Pickering Emulsions Stabilized by Food-Grade Particles As Innovative Delivery Systems for Bioactive Compounds, Advances in Colloid and Interface Science (2024)
45. Plga-Peg-Ra-Based Polymeric Micelles for Tumor Targeted Delivery of Irinotecan, Pharmaceutical Development and Technology (2018)
46. One-Step Wettability Patterning of Pdms Microchannels for Generation of Monodisperse Alginate Microbeads by in Situ External Gelation in Double Emulsion Microdroplets, Sensors and Actuators, B: Chemical (2019)
47. Novel Electrospun Polyvinyl Alcohol/Chitosan/Polycaprolactone-Diltiazem Hydrochloride Nanocomposite Membranes for Wound Dressing Applications, Emergent Materials (2024)
48. Development and Evaluation of Sustained-Release Propranolol Wax Microspheres, Journal of Microencapsulation (2001)
49. Poly(Glycerol Sebacate) Nanoparticles for Ocular Delivery of Sunitinib: Physicochemical, Cytotoxic and Allergic Studies, IET Nanobiotechnology (2019)
50. Development of Dry Powder Inhaler Containing Tadalafil-Loaded Plga Nanoparticles, Research in Pharmaceutical Sciences (2017)