Isfahan University of Medical Sciences

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Muscle and Oxidative Stress Publisher



Ghiasvand R1 ; Hariri M1
Authors
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Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease Published:2016


Abstract

This chapter describes muscular disease that may be caused by oxidative stress and how nutrition can help in the treatment of these diseases. It also discusses the most popular antioxidants in relation to muscle. Reactive oxygen species (ROS) can reduce lean body mass by stimulating the expression and activity of skeletal muscle protein degradation pathways. These compounding factors of oxidative stress may ultimately lead to muscle wasting and may cause muscular diseases such as dystrophy, myopathy, soreness, and cramps. Multiple enzymatic and nonenzymatic antioxidant defense systems are present in cells to protect the membranes and other cell organelles from the damaging effects of free radical reactions. These include vitamins C and E, coenzyme Q10, superoxide dismutase (SOD), and glutathione peroxidase. Free radicals and other factors like dehydration, electrolyte imbalance, calcium and magnesium deficiency, and low carbohydrate stores may cause muscle cramps. © 2016 by John Wiley & Sons, Inc.