Concomitant Presence of Jak2 V617f Mutation and Bcr-Abl Translocation in a Pregnant Woman With Polycythemia Vera

Concomitant Presence of Jak2 V617f Mutation and Bcr-Abl Translocation in a Pregnant Woman With Polycythemia Vera Publisher Pubmed

Toogeh G¹ ; Ferdowsi S² ; Naadali F³ ; Alimoghaddam K⁴ ; Ghavamzadeh A⁴ ; Shirkoohi R⁵ ; Ghaffari SH⁴

Show Affiliations

1. Hematology-Oncology and BMT Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
2. Hematology, Molecular Genetics, Cancer Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
3. Pathology Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4. Hematology-Oncology and BMT Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran 11411, Kargar Street, Iran
5. Molecular Genetics, Cancer Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Source: Medical Oncology Published:2011

Abstract

In 2007, a 27-year-old woman presented with mild splenomegaly. Blood counts showed hemoglobin (Hb): 17.8 g/dl, HCT: 56% and Red blood cells: 6.45 × 10 12/L. Bone marrow examination disclosed a hypercellular marrow. Molecular analysis showed the presence of the JAK2 V617F mutation and BCR-ABL/BCR mRNA b3a2 transcript. A diagnosis of BCR-ABL-positive polycythemia vera (PV) was made. In 2009, she had nulipar pregnancy and treated with interferon-alpha. She delivered a healthy girl infant at 37 weeks. This case report suggests that in a PV pregnant woman with a concomitant presence of JAK2 V617F mutation and BCR-ABL translocation, the administration of interferon during the pregnancy could lead to a safe pregnancy and delivery. © 2010 Springer Science+Business Media, LLC.

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Style	Citing Format
MLA	Toogeh G, et al.. "Concomitant Presence of Jak2 V617f Mutation and Bcr-Abl Translocation in a Pregnant Woman With Polycythemia Vera." Medical Oncology, vol. 28, no. 4, 2011, pp. 1555-1558.
APA	Toogeh G, Ferdowsi S, Naadali F, Alimoghaddam K, Ghavamzadeh A, Shirkoohi R, Ghaffari SH (2011). Concomitant Presence of Jak2 V617f Mutation and Bcr-Abl Translocation in a Pregnant Woman With Polycythemia Vera. Medical Oncology, 28(4), 1555-1558.
Chicago	Toogeh G, Ferdowsi S, Naadali F, Alimoghaddam K, Ghavamzadeh A, Shirkoohi R, Ghaffari SH. "Concomitant Presence of Jak2 V617f Mutation and Bcr-Abl Translocation in a Pregnant Woman With Polycythemia Vera." Medical Oncology 28, no. 4 (2011): 1555-1558.
Harvard	Toogeh G et al. (2011) 'Concomitant Presence of Jak2 V617f Mutation and Bcr-Abl Translocation in a Pregnant Woman With Polycythemia Vera', Medical Oncology, 28(4), pp. 1555-1558.
Vancouver	Toogeh G, Ferdowsi S, Naadali F, Alimoghaddam K, Ghavamzadeh A, Shirkoohi R, et al.. Concomitant Presence of Jak2 V617f Mutation and Bcr-Abl Translocation in a Pregnant Woman With Polycythemia Vera. Medical Oncology. 2011;28(4):1555-1558.
BibTex	@article{ author = {Toogeh G and Ferdowsi S and Naadali F and Alimoghaddam K and Ghavamzadeh A and Shirkoohi R and Ghaffari SH}, title = {Concomitant Presence of Jak2 V617f Mutation and Bcr-Abl Translocation in a Pregnant Woman With Polycythemia Vera}, journal = {Medical Oncology}, volume = {28}, number = {4}, pages = {1555-1558}, year = {2011} }
RIS	TY - JOUR AU - Toogeh G AU - Ferdowsi S AU - Naadali F AU - Alimoghaddam K AU - Ghavamzadeh A AU - Shirkoohi R AU - Ghaffari SH TI - Concomitant Presence of Jak2 V617f Mutation and Bcr-Abl Translocation in a Pregnant Woman With Polycythemia Vera JO - Medical Oncology VL - 28 IS - 4 SP - 1555 EP - 1558 PY - 2011 ER -

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