Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Synthesis and Antiproliferative Evaluation of Some Iron Chelators As Polyamine Transporter Targeting Agents Publisher



Nazifi SMR1 ; Sadeghialiabadi H1 ; Fassihi A1 ; Aliomrani M2 ; Saghaie L1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  2. 2. Department of Toxicology and Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences and Health Services, Isfahan, Iran

Source: Canadian Journal of Chemistry Published:2019


Abstract

A series of kojic acid derivatives based on monoamines, diamines, and triamines have been synthesized in good yield and purity. A spermidine (spd) rescue experiment was applied against MCF-7 cells to evaluate the polyamine transporter selectivity, and in vitro antiproliferative effects were determined against Hela and DU-145 cell lines. Overall, 5b showed the best selectivity for the polyamine transporter and antiproliferative effects. Therefore, the in-silico metabolism profile and ADMET properties of the title compounds were calculated by the PreADMET server. Additionally, physicochemical properties of ligands were predicted by using the Molinspiration online property calculation server. © 2019 Published by NRC Research Press.
Related Docs
1. Structure–Activity Relationship of Polyamine Conjugates for Uptake Via Polyamine Transport System, Structural Chemistry (2019)
Experts (# of related papers)
View all Related Experts
Lotfollah Saghaie Dehkordi (1)
Afshin Fassihi (1)