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International Consortium on Mammographic Density: Methodology and Population Diversity Captured Across 22 Countries Publisher Pubmed



Mccormack VA1 ; Burton A1 ; Dossantossilva I2 ; Hipwell JH3 ; Dickens C4 ; Salem D5 ; Kamal R6 ; Hartman M7 ; Lee CPL7, 8 ; Chia KS8 ; Ozmen V9 ; Aribal ME9 ; Flugelman AA10 ; Lajous M11, 12 Show All Authors
Authors
  1. Mccormack VA1
  2. Burton A1
  3. Dossantossilva I2
  4. Hipwell JH3
  5. Dickens C4
  6. Salem D5
  7. Kamal R6
  8. Hartman M7
  9. Lee CPL7, 8
  10. Chia KS8
  11. Ozmen V9
  12. Aribal ME9
  13. Flugelman AA10
  14. Lajous M11, 12
  15. Lopezriduara R12
  16. Rice M13
  17. Romieu I14
  18. Ursin G15, 16, 17
  19. Qureshi S18
  20. Ma H19
  21. Lee E17
  22. Van Gils CH20
  23. Wanders JOP20
  24. Vinayak S21
  25. Ndumia R21
  26. Allen S22
  27. Vinnicombe S23
  28. Moss S24
  29. Won Lee J25
  30. Kim J25
  31. Pereira A26
  32. Garmendia ML26
  33. Sirous R27
  34. Sirous M27
  35. Peplonska B28
  36. Bukowska A28
  37. Tamimi RM13
  38. Bertrand K29
  39. Nagata C30
  40. Kwong A31
  41. Vachon C32
  42. Scott C32
  43. Perezgomez B33
  44. Pollan M33
  45. Maskarinec G34
  46. Giles G35, 36
  47. Hopper J36
  48. Stone J37
  49. Rajaram N38
  50. Teo SH38, 39
  51. Mariapun S38
  52. Yaffe MJ40
  53. Schuz J41
  54. Chiarelli AM41
  55. Linton L42
  56. Boyd NF42

Source: Cancer Epidemiology Published:2016


Abstract

Mammographic density (MD) is a quantitative trait, measurable in all women, and is among the strongest markers of breast cancer risk. The population-based epidemiology of MD has revealed genetic, lifestyle and societal/environmental determinants, but studies have largely been conducted in women with similar westernized lifestyles living in countries with high breast cancer incidence rates. To benefit from the heterogeneity in risk factors and their combinations worldwide, we created an International Consortium on Mammographic Density (ICMD) to pool individual-level epidemiological and MD data from general population studies worldwide. ICMD aims to characterize determinants of MD more precisely, and to evaluate whether they are consistent across populations worldwide. We included 11755 women, from 27 studies in 22 countries, on whom individual-level risk factor data were pooled and original mammographic images were re-read for ICMD to obtain standardized comparable MD data. In the present article, we present (i) the rationale for this consortium; (ii) characteristics of the studies and women included; and (iii) study methodology to obtain comparable MD data from original re-read films. We also highlight the risk factor heterogeneity captured by such an effort and, thus, the unique insight the pooled study promises to offer through wider exposure ranges, different confounding structures and enhanced power for sub-group analyses. © 2015 Elsevier Ltd.
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