Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effects of Iron and Vitamin E on Endothelial Permeability of Aorta and Coronary Arteries in Rabbits on a High-Cholesterol Diet



Khazaei M1 ; Kajbaf M2 ; Kajbaf A2 ; Dashti GR3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Anatomy, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2011

Abstract

Background: Atherosclerosis is the leading cause of cardiovascular diseases. The relationship between enhanced endothelial permeability and initiation or progression of atherosclerosis has been indicated in previous studies. The aim of this study was to investigate the effects of iron (Fe) and vitamin E on endothelial permeability of aorta and coronary arteries in rabbits on a high-cholesterol diet. Methods: Thirty male rabbits were randomly divided into five groups of 6, namely control, hypercholesterolemic (HC), HC + Fe (50 mg/kg), HC + vitamin E (50 mg/kg), and HC + Fe + vitamin E. After 4 weeks, blood samples were taken and endothelial permeability was measured by Evans blue dye method. Findings: Administration of Fe and/or vitamin E improved serum lipid profile (P < 0.05). Administration of Fe could not change aortic endothelial permeability in hypercholesterolemic animals (P > 0.05). However, vitamin E reduced aortic endothelial permeability (P < 0.05). Fe and vitamin E did not alter coronary artery permeability (P > 0.05). Conclusion: It seems that the effects of Fe on atherosclerosis are not through the alteration of vascular permeability. However, reduced endothelial permeability may be a mechanism for beneficial effects of vitamin E on cardiovascular system. © 2011, Isfahan University of Medical Sciences(IUMS). All Rights Reserved.
Related Docs
View other Related Docs
1. Effect of Vitamin E on Apoptosis of the Endothelial Cells of the Carotid Arteries in Hypercholesterolemic Male Rabbits, ARYA Atherosclerosis (2023)
2. Effect of Experimentally Induced Metabolic Acidosis on Aortic Endothelial Permeability and Serum Nitric Oxide Concentration in Normal and High-Cholesterol Fed Rabbits, Archives of Medical Science (2012)
3. Effect of Ferrous and Vitamin E on Rabbit Serum Lipoproteins, Journal of Isfahan Medical School (2011)
4. Gender Difference in Endothelial Permeability of Aorta in Rabbits Consuming Normal or High-Cholesterol Diets, Iranian Journal of Medical Sciences (2003)
5. Biochemical Parameters of Iron Metabolism and Tg/Hdl-C Ratio in Patients With Coronary Artery Disease, Journal of Isfahan Medical School (2011)
6. Hyperinsulinemia May Have a Protective Role in the Early Stages of Atherosclerosis in Rabbit Model of Hypercholesterolemia, Journal of Diabetes and Metabolic Disorders (2012)
7. The Effect of Estrogen on Endothelial Permeability of Aorta and the Level of Serum Nitrite Concentration in Cholesterol-Fed Ovariectomized Rabbit, Iranian Biomedical Journal (2002)
8. Von Willebrand Factor, C-Reactive Protein, Nitric Oxide, and Vascular Endothelial Growth Factor in a Dietary Reversal Model of Hypercholesterolemia in Rabbit., Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia (2008)
Experts (# of related papers)
View all Related Experts
Sedigheh Asgary (24)
Mehdi Nematbakhsh (17)
Other Related Docs
9. Impacts of Fresh Lime Juice and Peel on Atherosclerosis Progression in an Animal Model, ARYA Atherosclerosis (2013)
10. The Effect of Aspirin on Serum Vascular Endothelial Growth Factor and Nitric Oxide Concentration in High-Cholesterol Fed Rabbits, ARYA Atherosclerosis (2007)
11. The Relation Between Body Iron Store and Ferritin, and Coronary Artery Disease, ARYA Atherosclerosis (2014)
12. Anti-Atherosclerotic Effects of Vitamins D and E in Suppression of Atherogenesis, Journal of Cellular Physiology (2017)
13. Reactive Oxygen Metabolites and Anti-Oxidative Defenses in Aspirin-Induced Gastric Damage in Rats: Gastroprotection by Vitamin E, Pathophysiology (2006)
14. Association of Vitamin D Deficiency and Coronary Artery Disease With Cardiovascular Risk Factors, Journal of Research in Medical Sciences (2012)
15. Effects of Oat and Wheat Bread Consumption on Lipid Profile, Blood Sugar, and Endothelial Function in Hypercholesterolemic Patients: A Randomized Controlled Clinical Trial, ARYA Atherosclerosis (2014)
16. The Effects of Olive Oil and Cholesterol Enriched Diets on Aortic Fatty Streak Development and Lipid Peroxidation in Rabbits, Nutrition and Health (2022)
17. Enhanced Plasma Level of Lipid Peroxidation in Iranians Could Be Improved by Antioxidants Supplementation, European Journal of Clinical Nutrition (1997)
18. Effect of Hypertension and Its Reverse on Serum Nitric Oxide Concentration and Vascular Permeability in Two-Kidney One-Clip Hypertensive Rats, General Physiology and Biophysics (2011)
19. Allium Hirtifolium Boiss: Radical Scavenging Property and the Lowering Effects on Blood Fibrinogen and Factor Vii, Life Science Journal (2012)
20. Effect of Vitamin Supplementation on Serum Oxidized Low-Density Lipoprotein Levels in Male Subjects With Cardiovascular Disease Risk Factors, Iranian Journal of Basic Medical Sciences (2012)
21. Endothelial Function and Dysfunction: Clinical Significance and Assessment, Journal of Research in Medical Sciences (2008)
22. The Sesame Lignan Sesamin Attenuates Vascular Permeability in Rats With Streptozotocin-Induced Diabetes: Involvement of Oxidative Stress, International Journal of Endocrinology and Metabolism (2011)
23. The Effects of L-Arginine on Serum Lipid Levels in Hypercholesterolemic Rabbits and Its in Vitro Antioxidant Activity, Journal of Isfahan Medical School (2007)
24. The Effects of Concurrent Hydroalcoholic Extract of Amaranthus Caudatus L. and Hypericum Perforatum L. of Fatty Streak Formation in Hypercholesterolemic Animals, African Journal of Pharmacy and Pharmacology (2011)
25. Effects of Ferulago Angulata Extract on Serum Lipids and Lipid Peroxidation, Evidence-based Complementary and Alternative Medicine (2014)
26. Lipid Lowering by Hydroalcoholic Extracts of Amaranthus Caudatus L. Induces Regression of Rabbits Atherosclerotic Lesions, Lipids in Health and Disease (2011)
27. Effect of Ascorbic Acid on the Right and Left Coronary Arteries of Male Rabbits Fed With High-Cholesterol Diet, ARYA Atherosclerosis (2007)
28. Low Dose of L-Arginine Does Not Change Endothelial Permeability of Aorta and Coronary Arteries in Rat, Pakistan Journal of Nutrition (2008)
29. Effects of Dietary Red Clover on Blood Factors and Cardiovascular Fatty Streak Formation in Hypercholesterolemic Rabbits, Phytotherapy Research (2007)
30. Effect of Cholesterol, Iron and Vitamin E on Protamine Deficiency and Dna Fragmentation of Male Rabbit Sperm, Journal of Isfahan Medical School (2014)
31. Effects of Alfalfa on Lipoproteins and Fatty Streak Formation in Hypercholesterolemic Rabbits, Pakistan Journal of Pharmaceutical Sciences (2008)
32. Clinical Investigation of the Acute Effects of Pomegranate Juice on Blood Pressure and Endothelial Function in Hypertensive Individuals, ARYA Atherosclerosis (2013)
33. The Effect of Ginger Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis of Clinical Trials, Phytomedicine (2018)
34. Protective and Curative Effects of Unconjugated Bilirubin on Gene Expression of Lox-1 and Inos in the Heart of Rats Receiving High-Fat Diet and Low Dose Streptozotocin: A Histomorphometric Approach, Journal of Inflammation (United Kingdom) (2024)
35. Antioxidant and Cytoprotective Effects of L-Serine on Human Endothelial Cells, Research in Pharmaceutical Sciences (2012)
36. The Prevention of Endothelial Dysfunction Through Endothelial Cell Apoptosis Inhibition in a Hypercholesterolemic Rabbit Model: The Effect of L-Arginine Supplementation, Lipids in Health and Disease (2008)
37. The Postprandial Effect of Apple Juice Intake on Some of the Biochemical Risk Factors of Atherosclerosis in Male Rabbit, Journal of Medicinal Plants Research (2009)
38. Does Vitamin C Improve Endothelial Function in Patients With Kawasaki Disease?, Journal of Research in Medical Sciences (2015)
39. Effect of Vitamin C Supplementation on Oxidative Stress and Lipid Profiles in Hemodialysis Patients, International Journal for Vitamin and Nutrition Research (2009)
40. The Effect of Maintenance and Reversal of Doca-Salt Hypertension on Extravasation of Macromolecules and Serum Nitric Oxide Concentration in Male Rats, Pathophysiology (2011)
41. Co-Administration of Silymarin and Deferoxamine Against Kidney, Liver and Heart Iron Deposition in Male Iron Overload Rat Model, International Journal of Preventive Medicine (2014)
42. L-Arginine Supplementation Enhances Enos Expression in Experimental Model of Hypercholesterolemic Rabbits Aorta, Pathophysiology (2009)
43. Citral Protects Human Endothelial Cells Against Hydrogen Peroxide-Induced Oxidative Stress; [Sitral, Insan Endotel Hucrelerini Hidrojen Peroksitin Neden Oldugu Oksidatif Strese Karsi Korur], Turkish Journal of Pharmaceutical Sciences (2020)
44. Effect of Gundelia Tournefortii L. on Some Cardiovascular Risk Factors in an Animal Model, Journal of HerbMed Pharmacology (2017)
45. Pomegranate Peel Extract Supplementation Increases the Number of Endothelial Progenitor Cells and Attenuates the Development of Atherosclerosis Plaque, Journal of Isfahan Medical School (2012)
46. Correlation Between Vitamin D Level and Coronary Artery Calcification, Journal of Research in Medical Sciences (2020)
47. Decreased Na+/K+-Atpase Activity and Altered Susceptibility to Peroxidation and Lipid Composition in the Erythrocytes of Metabolic Syndrome Patients With Coronary Artery Disease, Annals of Nutrition and Metabolism (2019)
48. Effect of Long-Term Vitamin C Intake on Vascular Endothelial Function in Diabetic Children and Adolescents: A Pilot Study, Journal of Research in Medical Sciences (2016)
49. Can Vitamin C Supplementation Reverse the Effects of Exercise Training in Polluted Air on Oxidative Stress Markers? a Randomized Controlled Trial, ARYA Atherosclerosis (2021)
50. Effect of Hydroalcoholic Extract of Hypericum Perforatum on Selected Traditional and Novel Biochemical Factors of Cardiovascular Diseases and Atherosclerotic Lesions in Hypercholesterolemic Rabbits: A Comparison Between the Extract and Lovastatin, Journal of Pharmacy and Bioallied Sciences (2012)