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Expression of Mir-148A in Human Meningioma Tumors



Moodi M1 ; Kheirollahi M1
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Authors Affiliations
  1. 1. Pediatrics Inherited Diseases Research Center AND Research Institute for Primordial Prevention of Non-communicable Diseases AND Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2015

Abstract

Background: Meningioma is one of the most prevalent brain tumors and is derived from meninges. Although, the tumor is usually benign and has limited numbers of genetic aberrations, but intracranial location often cause serious and lethal outcomes. Following role of phosphatase and tensin homolog (PTEN) protein, a tumor suppressor gene that is one of miR-148a targets in meningioma and as the microRNA has showed up regulation in brain tumor samples in microarray data, we assessed miR- 148a expression pattern in meningioma. Methods: We evaluated miR-148a expression among 25 meningioma and 4 normal tissues using realtime polymerase chain reaction method. Findings: The expression level of miR-148a showed significant difference between meningioma and normal tissues (P < 0.05). Conclusion: As a result, since there is a significance difference in the miR-148a expression in meningioma tumors compared to normal tissues, the microRNA might be considered as a marker in meningiomas tumors, with further investigations. © 2015, Isfahan University of Medical Sciences(IUMS). All rights reserved.
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