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In-Utero Exposure to Potential Sources of Indoor Air Pollution and Umbilical Cord Blood Leukocyte Telomere Length Publisher Pubmed



Dehdashti B1, 2, 3 ; Miri M4 ; Khanahmad H5 ; Feizi A6 ; Mohammadi F1 ; Rouholamin S7 ; Amin MM1, 2
Authors
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Authors Affiliations
  1. 1. Department of Environmental Health Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Environment Research Center, Research Institute for Primordial Prevention of Non- Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Student Research Committee, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Leishmaniasis Research Center, Department of Environmental Health, School of Public Health, Sabzevar University of Medical Sciences, Sabzevar, Iran
  5. 5. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Environmental Research Published:2024


Abstract

Indoor air pollution (IAP) has been associated with various adverse health effects. However, the evidence regarding such an association with leukocyte telomere length (LTL) in cord blood samples is still scarce. Therefore, the present study aimed to assess the relationship between exposure to indicators of IAP and LTL in umbilical cord blood samples. This cross-sectional study was based on 188 mother-newborn pairs who participated in our study between 2020 and 2022 in Isfahan, Iran. Umbilical LTL was measured by quantitative real-time polymerase chain reaction (qRT-PCR) technique. Linear mixed-effect models were used to assess the relationship between IAP indicators and umbilical LTL, adjusted for relevant covariates. The median (interquartile range (IQR)) of umbilical LTL was 0.92 (0.47). In fully adjusted models, frequency of using degreasing spray during pregnancy (times per month) (β = −0.047, 95% CI:0.09, −0.05, P-value = 0.02), using air freshener spray during pregnancy (β = −0.26, 95% CI: −0.5, −0.02, P-value = 0.03) and frequency of using insecticides during pregnancy (times per month) (β = −0.025, 95% CI: −0.047, −0.003, P-value = 0.02) were significantly associated with shorter umbilical LTL. There was a positive significant relationship between the frequency of using cleaning spray during pregnancy (times per month) with umbilical LTL (β = 0.019, 95% CI: 0.005, 0.033, P-value = 0.01). Furthermore, the direct connection of the parking with home and the frequency of using barbecue (times per week) were marginally associated with shorter umbilical LTL. For other indicators of IAP, we did not observe any statistically significant associations. Overall, this study suggested a negative association between prenatal exposure to IAP during pregnancy and umbilical LTL. © 2024 Elsevier Inc.
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