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Capillary Density: An Important Parameter in Nailfold Capillaroscopy Publisher Pubmed



Emrani Z1 ; Karbalaie A2 ; Fatemi A3 ; Etehadtavakol M1 ; Erlandsson BE2
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Authors Affiliations
  1. 1. Medical Image and Signal Processing Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Royal Institute of Technology (KTH), School of Technology and Health, Stockholm, SE-100 44, Sweden
  3. 3. Department of Rheumatology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Microvascular Research Published:2017


Abstract

Nailfold capillaroscopy is one of the various noninvasive bioengineering methods used to investigate skin microcirculation. It is an effective examination for assessing microvascular changes in the peripheral circulation; hence it has a significant role for the diagnosis of Systemic sclerosis with the classic changes of giant capillaries as well as the decline in capillary density with capillary dropout. The decline in capillary density is one of microangiopathic features existing in connective tissue disease. It is detectable with nailfold capillaroscopy. This parameter is assessed by applying quantitative measurement. In this article, we reviewed a common method for calculating the capillary density and the relation between the number of capillaries as well as the existence of digital ulcers, pulmonary arterial hypertension, autoantibodies, scleroderma patterns and different scoring system. © 2016 Elsevier Inc.
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