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Protective Effects of Curcumin Against Ischemia-Reperfusion Injury in the Liver Publisher Pubmed



Bavarsad K1 ; Riahi MM2 ; Saadat S1 ; Barreto G3, 4 ; Atkin SL5 ; Sahebkar A6, 7, 8
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Authors Affiliations
  1. 1. Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota D.C., Colombia
  4. 4. Instituto de Ciencias Biomedicas, Universidad Autonoma de Chile, Santiago, Chile
  5. 5. Weill Cornell Medicine Qatar, Doha, Qatar
  6. 6. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Pharmacological Research Published:2019


Abstract

Liver ischemia/reperfusion (I/R) injury is a major complication of hepatic surgery and transplantation. It is one of the leading causes of morbidity and mortality because of post-surgery hepatic dysfunction. Several studies have suggested different mechanisms are involved in the pathogenesis of I/R injury in the liver that includes oxidative stress, inflammation, mitochondria dysfunction, liver Kupffer cells (KCs) activation, vascular cell adhesion molecule overexpression, and facilitation of polymorphonuclear neutrophil injury. Curcumin is a natural product extracted from Curcuma longa that is known to suppress these pathways and as a result reduces liver ischemia-reperfusion injury. This paper gives an overview of the protective effects of curcumin against I/R injury in the liver and discusses the studies that have linked biological functions of curcumin with liver I/R injury improvement. © 2018 Elsevier Ltd
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