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Immune-Mediated Necrotizing Myopathy Following Vaccination With the Astrazeneca (Azd1222) Covid-19 Vaccine: A Case Report and Brief Review Publisher Pubmed



Ansari B1 ; Najafi MA1 ; Kheradmand M1 ; Najafi F2 ; Najafi MR1
Authors
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Authors Affiliations
  1. 1. Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Rothman Orthopedics, Thomas Jefferson University, Philadelphia, PA, United States

Source: Revue Neurologique Published:2023


Abstract

Immune-Mediated Necrotizing Myopathy (IMNM) after vaccination has been reported previously, however it is rare after COVID-19 vaccination. We report the first case of IMNM two weeks after vaccination with the AstraZeneca (AZD1222) COVID-19 vaccine. There was a probable temporal relationship between the COVID-19 vaccination and the development of IMNM due to lack of known causative factors for IMNM. This may have been due to 1) autoimmunity directly caused by the vaccine, 2) exacerbation of autoimmunity triggered by the vaccine or 3) autoimmune syndrome triggered by the vaccine adjutants. Further studies are needed to assess the underlying mechanisms. © 2023 Elsevier Masson SAS
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